147609-08-3Relevant academic research and scientific papers
Synthesis of Functionalized Nitriles by Microwave-Promoted Fragmentations of Cyclic Iminyl Radicals
Jackman, Mary M.,Im, Siyeon,Bohman, Seth R.,Lo, Concordia C. L.,Garrity, Amanda L.,Castle, Steven L.
supporting information, p. 594 - 598 (2017/12/28)
The synthesis of functionalized nitriles via microwave-promoted radical fragmentations of cyclic O-phenyl oxime ethers is reported. A variety of radical traps can be employed, permitting the generation of diverse adducts via C?O, C?C, C?N, or C?X bond formation. Other salient features include a simple and practical protocol, very short reaction times, and the avoidance of metal catalysts and toxic cyanide reagents. The utility of this method is demonstrated by the ring-distortion of a steroid-derived substrate.
Designing Homogeneous Bromine Redox Catalysis for Selective Aliphatic C?H Bond Functionalization
Becker, Peter,Duhamel, Thomas,Martínez, Claudio,Mu?iz, Kilian
supporting information, p. 5166 - 5170 (2018/03/28)
The potential of homogeneous oxidation catalysis employing bromine has remained largely unexplored. We herein show that the combination of a tetraalkylammonium bromide and meta-chloroperbenzoic acid offers a unique catalyst system for the convenient and s
Synthesis of Fused Dihydro-1,2,4-thiadiazolimines from Cyano-substituted Azides and Acyl Isothiocyanates
L'abbe, Gerrit,Sannen, Ingrid,Dehaen, Wim
, p. 27 - 30 (2007/10/02)
Organic azides, bearing a nitrile function at the γ- or δ-position, react with acyl isothiocyanates to give fused dihydro-1,2,4-thiadiazolimines.Representative examples are given.In the case of 2-cyanobenzylazide and benzoyl isothiocyanate, the formation of 9b is accompanied by two side products, 15 and 16.Mechanisms are presented to explain the formation of the products.
