14761-39-8

Basic information

• Product Name: 2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE
• Synonyms: BUTTPARK 95\04-11;AKOS BB-4895;1-(CHLOROACETYL)-4-PHENYLPIPERAZINE;2-CHLORO-1-(4-PHENYLPIPERAZINO)-1-ETHANONE;2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE;2-Chloro-1-(4-phenylpiperazino)ethan-1-one, tech;2-chloro-1-(4-phenyl-1-piperazinyl)ethanone;2-chloro-1-(4-phenylpiperazin-1-yl)ethanone
• CAS NO: 14761-39-8
• Molecular Formula: C₁₂H₁₅ClN₂O
• Molecular Weight: 238.71
• Mol File: 14761-39-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 71-73°C
• Boiling Point: 404.7°Cat760mmHg
• Flash Point: 198.5°C
• Appearance: /
• Density: 1.221g/cm³
• Vapor Pressure: 9.29E-07mmHg at 25°C
• Refractive Index: 1.569
• PKA: 2.91±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE(14761-39-8)
• EPA Substance Registry System: 2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE(14761-39-8)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• HazardClass: IRRITANT
• Hazardous Substances Data: 14761-39-8(Hazardous Substances Data)

Usage

General Description

2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE is a chemical compound that belongs to the class of piperazine derivatives and is used in the field of medicinal chemistry. It is a chlorinated ketone that contains a piperazine ring and a phenyl group. 2-CHLORO-1-(4-PHENYLPIPERAZINO)ETHAN-1-ONE has potential applications in the development of pharmaceutical drugs and may exhibit central nervous system activity, such as anxiolytic or sedative properties. As a chemical intermediate, it may be used in the synthesis of various biologically active compounds and drug candidates. Its molecular structure and properties make it a valuable building block for the design and synthesis of new chemical entities with potential therapeutic effects.

InChI:InChI=1/C12H15ClN2O/c13-10-12(16)15-8-6-14(7-9-15)11-4-2-1-3-5-11/h1-5H,6-10H2

Upstream product

• 4004-95-9 1-phenylpiperazine hydrochloride 
• 79-04-9 chloroacetyl chloride 
• 92-54-6 4-phenyl-1-piperazine 

Downstream Products

• 21057-36-3 2-azido-1-(4-phenylpiperazin-1-yl)ethanone 
• 1092848-55-9 (-)-(4aS,10aS)-trans-2-(7-methoxy-2,3,4a,5,6,10b-hexahydro-1H-benzo[f]quinolin-4-yl)-1-(4-phenylpiperazin-1-yl)ethanone 
• 53646-60-9 2-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]isoindoline-1,3-dione 
• 81262-71-7 2‐{[2‐oxo‐2‐(4‐phenylpiperazin‐1‐yl)ethyl]thio}‐3‐phenylquinazolin‐4(3H)‐one 

Relevant articles and documents

Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety

Tyrosinase (TYR, EC 1.14.18.1) plays a pivotal role in mammalian melanogenesis and enzymatic browning of plant-derived food. Therefore, tyrosinase inhibitors (TYRIs) can be of interest in cosmetics and pharmaceutical industries as depigmentation compounds

A new n-substituted 1h-isoindole-1,3(2h)-dione derivative— synthesis, structure and affinity for cyclooxygenase based on in vitro studies and molecular docking

Isoindoline-1,3-dione derivatives constitute an important group of medicinal substances. In this study, nine new 1H-isoindole-1,3(2H)-dione derivatives and five potential pharmacophores were obtained in good yield (47.24–92.91%). The structure of the new

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

In this study, some benzimidazole-oxadiazole derivatives were synthesised and tested for their in vitro anticancer activities on five cancer cell lines, including HeLa, MCF7, A549, HepG2 and C6. Their structures were elucidated by IR, 1H-NMR,