147624-38-2Relevant academic research and scientific papers
Total Synthesis of (-)-Ovatolide
Delgado, Antonio,Clardy, Jon
, p. 2862 - 2866 (2007/10/02)
The total synthesis of (-)-ovatolide (1), a tetracyclic indole-containing β-glucosyl derivative with an unusual pyranodioxocan-6-one system, is described.The β-glucosidic linkage arose from regio- and stereocontrolled reaction of a protected 1,2-epoxyglucal derivative with 4-hydroxy-5-(benzyloxy)indole, and a lactonization reaction afforded the central dioxocanone system.An alternative strategy that afforded the tetracyclic framework as a mixture of epimers is also described.
