147637-19-2

Upstream product

• 146516-81-6 7-chloro-3-hydroxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 
• 6833-13-2 2-chlorobenzanilide 

Downstream Products

• 147637-25-0 7-Chloro-1-(2-methoxy-phenyl)-1,3-dihydro-isobenzofuran-1-ol 
• 1028275-47-9 7-Chloro-1-(2,4-dimethoxy-6-methoxymethyl-phenyl)-1,3-dihydro-isobenzofuran-1-ol 
• 1026931-80-5 7-Chloro-1-(2-methoxymethyl-phenyl)-1,3-dihydro-isobenzofuran-1-ol 

Relevant academic research and scientific papers

Application of organolithium and related reagents in synthesis. Part 21. Synthetic strategies based on orthro-aromatic metallation. A concise regiospecific synthesis of arylnaphthalanes as precursors of naphthylisoquinoline alkaloids

A novel procedure is described for synthesising regioselectively substituted biaryls such as 12. It involves converting phthalides 4, via cycloaddition of dimethyl acetylenedicarboxylate to 1-arylisobenzofurans 6, into dimethyl 1-arylnaphthalene-2,3-dicar

Application of organolithium and related reagents in synthesis. Part 13. Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzoic acids into 4-hydroxy-1-arylnaphthalenes

The synthesis of the 3-unsubstituted phthalides (5) and their conversion into 1-hydroxy-1-arylphthalans (8), very useful precursors of isobenzofurans (10) and subsequent cycloaddition of them to dimethyl acetylenedicarboxylate as a way of regiospecific transformation of benzoic acids into dimethyl 4-hydroxy-1-(2-methoxyphenyl)naphthalene-2,3-dicarboxylates (12) (biaryls highly substituted around the axis), is described.