14764-32-0Relevant academic research and scientific papers
Preparation method of key intermediate 2-ethyl butyraldehyde of 2-ethyl butyric acid
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Paragraph 0013-0015, (2017/07/19)
The invention provides a preparation method of a key intermediate, 2-ethyl butyraldehyde, of 2-ethyl butyric acid, wherein the preparation method includes the steps of: adding an ethyl magnesium halide Grignard reagent to a protected alpha-halogenated aldehyde (I) solution, and performing a stirring reaction for 1-10 h at a certain temperature; performing post-treatment and de-protecting the product to obtain the 2-ethyl butyraldehyde. A route in the process in represented as follows. The method has short route and high usage ratio, is low in cost and easy to industrialize, and avoids defects in conventional methods.
An overlooked short entry to 2-alkyliden-1,3-dioxolanes. Highly reactive ketene acetals.
Aben, R. W. M.,Scheeren, J. W.
, p. 399 - 400 (2007/10/02)
2-Alkaliden-1,3-dioxolanes can be prepared surprisingly easily from the corresponding 2-bromoacetals by dehydrobromination with potassium tert. butoxide.The method has a wide scope and gives access to ketene acetals which cannot be prepared by other methods.The application of mono substituted cyclic ketene acetals in the lewis acid catalyzed stereoselective formation of cis oxetanes from aldehydes is illustrated.
