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147657-22-5 Usage


Calcipotriol Monohydrate is a low-calcemic vitamin D receptor (VDR) agonist, which is approximately 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). It is a white or almost white, crystalline powder that binds to the VDR, increasing the transcription factor AP-1, which is crucial for keratinocyte differentiation. Calcipotriol Monohydrate also reduces the expression of JunB protein, a transcriptional activator in the inflammatory response, and induces the expression of thymic stromal lymphopoietin, which promotes T-cell differentiation in keratinocytes.


Used in Pharmaceutical Industry:
Calcipotriol Monohydrate is used as a topical treatment agent for the treatment of plaque psoriasis in adult patients. It is often combined with betamethasone dipropionate, a corticosteroid, to enhance the therapeutic effects and manage the symptoms of psoriasis effectively.
Used in Dermatology:
Calcipotriol Monohydrate is used as a skin treatment agent to promote keratinocyte differentiation and reduce inflammation in the skin. Its anti-inflammatory properties make it a valuable component in the treatment of various skin conditions, including psoriasis.
Used in Research and Development:
Calcipotriol Monohydrate is used as a research compound for studying the effects of vitamin D analogues on cellular processes, such as cell differentiation and inflammation. Its unique properties allow scientists to explore new therapeutic approaches for various skin disorders and other conditions that involve the vitamin D receptor.

Check Digit Verification of cas no

The CAS Registry Mumber 147657-22-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,6,5 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147657-22:
155 % 10 = 5
So 147657-22-5 is a valid CAS Registry Number.

147657-22-5 Well-known Company Product Price

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  • Sigma-Aldrich

  • (Y0000473)  Calcipotriol monohydrate  European Pharmacopoeia (EP) Reference Standard

  • 147657-22-5

  • Y0000473

  • 1,880.19CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017


1.1 GHS Product identifier


1.2 Other means of identification

Product number -
Other names Calcipotriol (monohydrate)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147657-22-5 SDS

147657-22-5Upstream product

147657-22-5Downstream Products

147657-22-5Relevant articles and documents

Procedure to obtain calcipotriol hydrate


Page/Page column 1, (2008/12/06)

Procedure to obtain the hydrate of calcipotriol. A procedure is described, used to obtain the hydrate of calcipotriol, which consists of the reaction of anhydrous calcipotriol in water, in the absence of organic solvents.

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