147657-22-5 Usage
Description
Calcipotriol (hydrate) is a low-calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D3). Binding of calcipotriol (hydrate) to the VDR increases AP-1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-cell differentiation in keratinocytes.
Chemical Properties
White or almost white, crystalline powder.
Uses
Vitamin D analogue.
Definition
ChEBI: A hydrate that is the monohydrate form of calcipotriol. It is used in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.
Check Digit Verification of cas no
The CAS Registry Mumber 147657-22-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,6,5 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147657-22:
(8*1)+(7*4)+(6*7)+(5*6)+(4*5)+(3*7)+(2*2)+(1*2)=155
155 % 10 = 5
So 147657-22-5 is a valid CAS Registry Number.
InChI:InChI=1/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25?,26+,27-;/m1./s1
147657-22-5Relevant articles and documents
Procedure to obtain calcipotriol hydrate
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Page/Page column 1, (2008/12/06)
Procedure to obtain the hydrate of calcipotriol. A procedure is described, used to obtain the hydrate of calcipotriol, which consists of the reaction of anhydrous calcipotriol in water, in the absence of organic solvents.
