147657-22-5 Usage
Uses
Used in Pharmaceutical Industry:
Calcipotriol Monohydrate is used as a topical treatment agent for the treatment of plaque psoriasis in adult patients. It is often combined with betamethasone dipropionate, a corticosteroid, to enhance the therapeutic effects and manage the symptoms of psoriasis effectively.
Used in Dermatology:
Calcipotriol Monohydrate is used as a skin treatment agent to promote keratinocyte differentiation and reduce inflammation in the skin. Its anti-inflammatory properties make it a valuable component in the treatment of various skin conditions, including psoriasis.
Used in Research and Development:
Calcipotriol Monohydrate is used as a research compound for studying the effects of vitamin D analogues on cellular processes, such as cell differentiation and inflammation. Its unique properties allow scientists to explore new therapeutic approaches for various skin disorders and other conditions that involve the vitamin D receptor.
Check Digit Verification of cas no
The CAS Registry Mumber 147657-22-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,6,5 and 7 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147657-22:
(8*1)+(7*4)+(6*7)+(5*6)+(4*5)+(3*7)+(2*2)+(1*2)=155
155 % 10 = 5
So 147657-22-5 is a valid CAS Registry Number.
InChI:InChI=1/C27H40O3.H2O/c1-17(6-13-25(29)20-8-9-20)23-11-12-24-19(5-4-14-27(23,24)3)7-10-21-15-22(28)16-26(30)18(21)2;/h6-7,10,13,17,20,22-26,28-30H,2,4-5,8-9,11-12,14-16H2,1,3H3;1H2/b13-6+,19-7+,21-10-;/t17-,22-,23-,24+,25?,26+,27-;/m1./s1
147657-22-5Relevant academic research and scientific papers
Procedure to obtain calcipotriol hydrate
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Page/Page column 1, (2008/12/06)
Procedure to obtain the hydrate of calcipotriol. A procedure is described, used to obtain the hydrate of calcipotriol, which consists of the reaction of anhydrous calcipotriol in water, in the absence of organic solvents.
ISOMERISATION OF PHARMACEUTICAL INTERMEDIATES
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Page/Page column 21, (2008/06/13)
The present invention relates to an isomerisation method of vitamin D analogues, such as compounds useful for the synthesis of calcipotriol, and to and to the use of a flow- through photoreactor or continuous flow photoreactor reactor for making said vitamin D analogues. The present invention relates further to the use of intermediates produced with said method for making calcipotriol or calcipotriol monohydrate, or pharmaceutical formulations thereof.
