147658-54-6Relevant articles and documents
Eco-friendly combination of the immobilized PGA enzyme and the s-phacm protecting group for the synthesis of cys-containing peptides
Góngora-Benítez, Miriam,Basso, Alessandra,Bruckdorfer, Thomas,Royo, Miriam,Tulla-Puche, Judit,Albericio, Fernando
, p. 16166 - 16176 (2013/02/23)
Enzyme-labile protecting groups have emerged as a green alternative to conventional protecting groups. These groups introduce a further orthogonal dimension and eco-friendliness into protection schemes for the synthesis of complex polyfunctional organic molecules. S-Phacm, a Cys-protecting group, can be easily removed by the action of a covalently immobilized PGA enzyme under very mild conditions. Herein, the versatility and reliability of an eco-friendly combination of the immobilized PGA enzyme and the S-Phacm protecting group has been evaluated for the synthesis of diverse Cys-containing peptides.