147672-45-5Relevant academic research and scientific papers
Structure-Activity Relationships of C1 and C6 Side Chains of Zaragozic Acid A Derivatives
Ponpipom, Mitree M.,Girotra, Narindar N.,Bugianesi, Robert L.,Roberts, Cathleen D.,Berger, Gregory D.,et al.
, p. 4031 - 4051 (2007/10/02)
Systematic modification of the C6 acyl side chain of zaragozic acid A, a potent squalene synthase inhibitor, was undertaken to improve its biological activity.Simplification of the C6 side chain to the octanoyl ester has deleterious effects; increasing th
Chemoselective removal and replacement of the C-4' and C-6 acyl esters of zaragozic acid A
Burk,Berger,Bugianesi,Girotra,Parsons,Ponpipom
, p. 975 - 978 (2007/10/02)
An efficient chemical sequence is described for the modification of the C-4' and C-6 positions of zaragozic acid A. Key reactions include the specific conditions devised for selective removal of either the C-4' acetate or the C-6 acyl chain. The resultant
