1476747-08-6Relevant academic research and scientific papers
Unexpected copper-catalyzed cascade synthesis of quinazoline derivatives
Chen, Zhongyan,Chen, Jiuxi,Liu, Miaochang,Ding, Jinchang,Gao, Wenxia,Huang, Xiaobo,Wu, Huayue
, p. 11342 - 11348 (2013)
The first example of a copper-catalyzed cascade reaction of (2-aminophenyl)methanols with aldehydes using the combination of cerium nitrate hexahydrate and ammonium chloride has been developed, leading to a wide range of 2-substituted quinazolines in moderate to excellent yields. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. Thus, the method represents a convenient and practical strategy for synthesis of 2-substituted quinazoline derivatives.
