1476768-63-4Relevant academic research and scientific papers
Synthesis of 3-Hydroxyisoindolin-1-ones through 1,4-Dioxane-Mediated Hydroxylhydrative aza-Cyclization of 2-Alkynylbenzamide in Water
Dong, Wenbi,Liu, Renzhi,Potkin, Vladimir Ivanovich,Qiu, Guanyinsheng,Xie, Wenlin,Yadav, Sarita,Yang, Min,Zhou, Hongwei
, p. 5312 - 5320 (2020)
In this work, 1,4-dioxane-mediated hydroxylhydrative aza-cyclization of 2-alkynylbenzamide is developed for the synthesis of 3-hydroxylisoindolin-1-ones. The transformation proceeds smoothly in water with good yields and a broad reaction scope. Mechanistic studies show that regioselective brimonative 5-exo-dig aza-cyclization, bromohydration of the resulting alkene groups, and hydrolysis of dibromo compounds are involved. Compared to the traditional methodologies, the synthetic procedure reported herein represents a cleaner route toward 3-hydroxylisoindolin-1-ones.
Palladium-catalyzed intramolecular cyclization of 2-iodobenzamides: An efficient synthesis of 3-acyl isoindolin-1-ones and 3-hydroxy-3-acyliso-indolin- 1-ones
Chen, Wanli,Jin, Lina,Zhu, Yinghong,Cao, Xiaoji,Zheng, Lebin,Mo, Weimin
supporting information, p. 1856 - 1860 (2013/09/12)
Palladium-catalyzed intramolecular cyclization of 2-iodobenzamides with a 2-oxoethyl function group on the nitrogen atom moiety is presented, providing an efficient method for the synthesis of 3-acyl isoindolin-1-ones and 3-hydroxy-3-acylisoindolin-1-ones under mild conditions in moderate yields. Georg Thieme Verlag Stuttgart · New York.
