1476777-06-6

Basic information

• Product Name: Niraparib metabolite M1
• Synonyms: Niraparib metabolite M1
• CAS NO: 1476777-06-6
• Molecular Formula: C19H19N3O2
• Molecular Weight: 321.37306
• Mol File: 1476777-06-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 442.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: -2.18±0.30(Predicted)
• CAS DataBase Reference: Niraparib metabolite M1(CAS DataBase Reference)
• NIST Chemistry Reference: Niraparib metabolite M1(1476777-06-6)
• EPA Substance Registry System: Niraparib metabolite M1(1476777-06-6)

Safety Data

• Hazardous Substances Data: 1476777-06-6(Hazardous Substances Data)

Usage

Description

Niraparib metabolite M1 is a metabolite of Niraparib, a novel oral poly(ADP-ribose) polymerase (PARP) inhibitor that is efficacious in BRCA-1 and -2 mutant tumors. It is formed as a result of the metabolism of Niraparib in the body and may have potential implications for the drug's efficacy and safety profile.

Uses

Used in Pharmaceutical Industry:
Niraparib metabolite M1 is used as an impurity in the development and manufacturing of Niraparib (N481400), a PARP inhibitor. Its presence and concentration in the drug product are closely monitored to ensure the safety and efficacy of the medication for patients with BRCA-1 and -2 mutant tumors.
Used in Research and Development:
Niraparib metabolite M1 is used as a research tool for studying the metabolism, pharmacokinetics, and pharmacodynamics of Niraparib. Understanding the properties and behavior of this metabolite can help researchers optimize the drug's formulation, dosing, and administration, potentially leading to improved treatment outcomes for patients with BRCA-1 and -2 mutant tumors.
Used in Quality Control and Regulatory Compliance:
Niraparib metabolite M1 is used in the quality control processes of Niraparib drug products to ensure that the impurity levels are within acceptable limits as per regulatory guidelines. This helps maintain the safety, efficacy, and overall quality of the medication, ensuring that patients receive a high-quality and reliable treatment option for their condition.