1476799-51-5Relevant academic research and scientific papers
Convenient synthesis of new N-3-substituted pyrido[1′,2′:1,5] pyrazolo[3,4- d ]pyrimidine-2,4(1 H,3 H)-dione derivatives
Belaroussi, Rabia,El Bouakher, Abderrahman,Marchivie, Mathieu,Massip, Stephane,Jarry, Christian,El Hakmaoui, Ahmed,Guillaumet, Gerald,Routier, Sylvain,Akssira, Mohamed
, p. 2557 - 2566 (2013)
Previously unknown N-3-substituted pyrido[1′,2′:1,5]pyrazolo[3, 4-d]pyrimidine derivatives were synthesized by a straightforward four-step synthesis. Starting from a 1-aminopyridinium salt, dimethyl acetylenedicarboxylate condensation followed by a fully regioselective saponification led to a pyrazolo[1,5-a]pyridine monoester as a key intermediate. A Curtius rearrangement directly followed by amine condensation afforded a urea library. A final pyrimidine ring closure resulted in achievement of the heterocyclic construction. This straightforward strategy provides an efficient method to easily access a library of rare tricyclic scaffolds and highly valuable derivatives.
