1476801-88-3Relevant academic research and scientific papers
One-pot synthesis of novel 2-(Thiazol-2-yl)-4,5-dihydropyridazin-3(2 H)-one derivatives catalyzed by activated KSF
Mahmoodi, Nosrat O.,Safari, Niloufar,Sharifzadeh, Bahman
, p. 245 - 250 (2013/12/04)
A series of 2-(thiazol-2-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by one-pot multicomponent cyclocondensation of ketoacid, thiosemicarbazide, and phenacyl bromide using catalytical amount of KSF in EtOH under reflux. The straightforward synthesis, presence of two important class of heterocyclic rings in the individual molecule, easy workup of the products, rapid reaction, mild conditions, and good to excellent yields are notable features of this protocol. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.]
