147687-15-8Relevant articles and documents
Rearrangement of S-(2-aminoethyl) thiophosphates to N-(2-mercaptoethyl)- phosphoramidates
Chen, Menglin,Maetzke, Alice,Knak Jensen, Svend J.,Gothelf, Kurt V.
, p. 5826 - 5833 (2007)
A novel rearrangement of S-(2-aminoethyl) thiophosphates to N-(2-mercaptoethyl)phosphoramidates was discovered and developed. The reaction proceeds smoothly at room temperature under basic conditions and the resulting thiol could subsequently be alkylated. The reaction mechanism is investigated by electron structure calculations using density functional theory at the B3LYP/6-31G(d) and B3LYP/6-311+G(d,p) levels. The calculations indicate that the reaction proceeds in a two step process when two explicit solvent molecules are included. In the presence of water the rearrangement reaction proceeds in competition with hydrolysis. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.
Nucleic acid synthesizing dimer amidite and nucleic acid synthesizing method
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Page/Page column 100, (2015/01/16)
To provide an excellent dimer amidite which can be subjected to purification, preferably, whose protective groups can be removed under mild conditions, and a method for synthesizing a nucleic acid using the dimer amidite, a dimer amidite having a structur
