147698-43-9Relevant academic research and scientific papers
Heterocyclic ureas: Inhibitors of acyl-CoA:cholesterol O- acyltransferase as hypocholesterolemic agents
White, Andrew D.,Creswell, Mark W.,Chucholowski, Alexander W.,Blankley, C. John,Wilson, Michael W.,Bousley, Richard F.,Essenburg, Arnold D.,Hamelehle, Katherine L.,Krause, Brian R.,Stanfield, Richard L.,Dominick, Mark A.,Neub, Martin
, p. 4382 - 4395 (2007/10/03)
A series of diaryl-substituted heterocyclic ureas was prepared, and their ability to inhibit acyl-CoA:cholesterol O-acyltransferase (ACAT) in vitro and to lower plasma total cholesterol in cholesterol-fed animal models in vivo was examined. N-(2,6-Diisopr
3-heteroatom containing urea and thiourea ACAT inhibitors
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, (2008/06/13)
Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula STR1 wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms selected from nitrogen, oxygen and sulfur, and R1, R2 and R3 are hydrogen, flourine, chlorine, bromine, a straight or branched alkyl group having from 1 to 6 carbon atoms, a straight or branched alkoxy group having from 1 to 6 carbon atoms, substituted or unsubstituted benzoyl, substituted or unsubstituted benzoyl, substituted or unsubstituted phenyl, amino or substituted amino or a carboxy group.
