147699-99-8Relevant academic research and scientific papers
The adenosine A2A antagonistic properties of selected C8-substituted xanthines
Van Der Walt, Mietha M.,Terre'Blanche, Gisella,Petzer, Anel,Lourens, Anna C.U.,Petzer, Jacobus P.
, p. 49 - 58 (2013)
The adenosine A2A receptor is considered to be an important target for the development of new therapies for Parkinson's disease. Several antagonists of the A2A receptor have entered clinical trials for this purpose and many research
Inhibition of monoamine oxidase B by analogues of the adenosine A2A receptor antagonist (E)-8-(3-chlorostyryl)caffeine (CSC)
Vlok, Nevil,Malan, Sarel F.,Castagnoli Jr., Neal,Bergh, Jacobus J.,Petzer, Jacobus P.
, p. 3512 - 3521 (2007/10/03)
The adenosine A2A receptor has emerged as a possible target for the treatment of Parkinson's disease (PD). Evidence suggests that antagonism of the A2A receptor not only improves the symptoms of the disease but may also protect again
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists
Jacobson,Gallo-Rodriguez,Melman,Fischer,Maillard,Van Bergen,Van Galen,Karton
, p. 1333 - 1342 (2007/10/02)
A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A2-selective adenosine receptor antagonists, and the potency at rat brain A1- and A2-receptors was studied in radioligand bi
