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147711-26-0

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147711-26-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 147711-26-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,7,1 and 1 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 147711-26:
(8*1)+(7*4)+(6*7)+(5*7)+(4*1)+(3*1)+(2*2)+(1*6)=130
130 % 10 = 0
So 147711-26-0 is a valid CAS Registry Number.

147711-26-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 7,8-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one

1.2 Other means of identification

Product number -
Other names 7,8,4-trihydroxyflavone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:147711-26-0 SDS

147711-26-0Relevant articles and documents

Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ)

Sun, Haopeng,Chen, Feihong,Wang, Xiaojian,Liu, Zongliang,Yang, Qian,Zhang, Xiaojin,Zhu, Jia,Qiang, Lei,Guo, Qinglong,You, Qidong

, p. 110 - 123 (2012/07/28)

Previously we have reported a series of gambogic acid's analogs and have identified a compound that possessed comparable in vitro growth inhibitory effect as gambogic acid. However, their target protein as well as the key pharmacophoric motifs on the target have not been identified yet. Herein we report that gambogic acid and its analogs inhibit the activity of IκB Kinase-beta (IKKβ) through suppressing the activation of TNFα/NF-κB pathway, which in turn induces A549 and U251 cell apoptosis. IKKβ can serve as one of gambogic acid's targets. The preparation of the compounds was carefully discussed in the article. Caged 4-oxa-tricyclo[4.3.1.03,7]dec-2-one xanthone, which was identified as the pharmacophoric scaffold, represents a promising therapeutic agent for cancer and useful probe against NF-κB pathway.

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