147723-92-0 Usage
General Description
The chemical compound known as "(2E)-3-[4-(aminosulfonyl)phenyl]acrylic acid" is a derivative of acrylic acid that contains a phenyl group substituted with an aminosulfonyl group. It is classified as an unsaturated carboxylic acid and is commonly used in organic synthesis and pharmaceutical research. (2E)-3-[4-(AMINOSULFONYL)PHENYL]ACRYLIC ACID has been studied for its potential medicinal properties, including its anti-inflammatory and antioxidant effects. Additionally, it has been investigated for its potential use in the treatment of conditions such as rheumatoid arthritis and cancer. The chemical structure of "(2E)-3-[4-(aminosulfonyl)phenyl]acrylic acid" makes it a versatile building block for the synthesis of various organic compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 147723-92-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,7,2 and 3 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 147723-92:
(8*1)+(7*4)+(6*7)+(5*7)+(4*2)+(3*3)+(2*9)+(1*2)=150
150 % 10 = 0
So 147723-92-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H9NO4S/c10-15(13,14)8-4-1-7(2-5-8)3-6-9(11)12/h1-6H,(H,11,12)(H2,10,13,14)/b6-3+
147723-92-0Relevant articles and documents
Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors
Angeli, Andrea,Bozdag, Murat,Carta, Fabrizio,Gumus, Arzu,Peat, Thomas S.,Selleri, Silvia,Supuran, Claudiu T.
supporting information, (2021/08/16)
We report for the first time a small series of compounds endowed in vitro with inhibitory properties for the human (h) expressed Carbonic Anhydrase (CAs, E.C. 4.2.1.1) enzymes of physiological interest (i.e. I, II, VA, IX and XII) and bearing the pyrazolo[1,5-a]pyrimidine (PP) scaffold at the tail section. Among the series reported, 1a-3a, 7a, 8a, 1b and 2b resulted effective ligands and with good selectivities for the hCAs II, IX or XII. In consideration of the nearly matching KI values of 7a for both the hCA II and IX (i.e. 26.4 and 23.0 nM respectively) we explored its binding mode within the CA IX mimic isoform by means of X-ray crystal experiments on the corresponding adduct.
