14773-00-3Relevant articles and documents
Efficient and selective microwave Oppenauer oxidation of sterol derivatives
Négrel, Sophie,Brunel, Jean Michel
, (2021)
An improved, fast, and accurate procedure for regioselective microwave Oppenauer oxidation of sterol derivatives is reported leading to the expected corresponding ketosterols in moderate to excellent isolated yields ranging from 58 to 81%. The influence of different parameters dealing with the nature of the solvent and of the Lewis acid/ketone couple used, the reaction temperature as well as the hydrolysis conditions were also investigated on the outcome of the reaction.
METHOD AND COMPOSITIONS FOR FORMING A COPPER-CONTAINING COMPLEX AND USES THEREOF
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, (2019/05/22)
Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula (I): wherein R is -OH or -O-CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula (I). Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula (I) optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula (I).
A stereoselective synthesis of the allo-bile acids from the 5β-isomers
Li, Qingjiang,Tochtrop, Gregory P.
supporting information; experimental part, p. 4137 - 4139 (2011/09/19)
The allo-bile acids are a subset of the family of steroidal detergents found in most vertebrates. Because there are no major biological feedstocks for isolation of the allo-bile acids, they must be synthesized from the abundant 5β-reduced isomers. Here we report a general set of methods for the synthesis of allo-bile acids from the corresponding 5-β isomers demarcated by a selective C-3 oxidation, IBX unsaturation, and stereoselective saturation.
