147742-82-3Relevant articles and documents
Synthesis of Some New Isoxazolylacetic Acid Derivatives
Gombos, Zsuzsanna,Nyitrai, Jozsef,Doleschall, Gabor,Kolonits, Pal,Parkanyi, Laszlo,Kalman, Alajos
, p. 139 - 144 (2007/10/02)
(3-Chloroisoxazol-5-yl)acetic acid 1, a known acylating agent, useful for the synthesis of semi-synthetic cephalosporins was synthesized by a new route.Several α-substituted 3-chloroisoxazolylacetic acids 9a,b; 10a,b and 15, potential acylating agents for semi-synthetic β-lactams, were also prepared.The (E)- and (Z)-3-chloro-α-methoxyiminoisoxazol-5-ylacetic acids 10a,b were separated and their structures unambiguously determined by 1H NMR spectroscopic and X-ray measurements.