1477482-31-7Relevant academic research and scientific papers
Stereoselective synthesis of the C13-C28 subunit of (-)-laulimalide utilizing an α-chlorosulfide intermediate
Raghavan, Sadagopan,Samanta, Pradip Kumar
, p. 1983 - 1987 (2013)
A stereoselective route to the C13-C28 subunit of (-)-laulimalide is described. l-Tartaric acid is the source of the hydroxy groups at C19 and C20. An α-chlorosulfide is employed as the key intermediate for the creation of the C17-C18 bond and the C16-C17 double bond was introduced using the Mislow-Braverman rearrangement and Hutchin's dexoxygenation with concomitant double bond transposition reaction. The C15 and C23 stereogenic centers were created using catalytic asymmetric reactions. The trisubstituted and trans-disubstituted alkenes were created stereoselectively by taking advantage of ring-closing metathesis and the Julia-Kocienski olefination reaction, respectively. Georg Thieme Verlag Stuttgart, New York.
Ti(II) and Rh(I) Complexes as Reagents toward a Thapsigargin Core
Sanogo, Youssouf,Othman, Raja Ben,Dhambri, Sabrina,Selkti, Mohamed,Jeuken, Alan,Prunet, Jo?lle,Férézou, Jean-Pierre,Ardisson, Janick,Lannou, Marie-Isabelle,Sorin, Geoffroy
, p. 5821 - 5830 (2019)
A novel approach toward the [5 - 7]fused bicyclic core of thapsigargin, a subnanomolar inhibitor of the endo/sarcoplasmic calcium ATPase (SERCA), is presented. The synthetic route includes an original Ti(II)-mediated hydroxy-directed reductive coupling of
