147749-98-2Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF N,N′- DISUBSTITUTED OXABISPIDINES
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Page/Page column 40-41, (2010/11/25)
There is provided a process for the preparation of a sulfonic acid salt of formula I, or a solvate thereof, which process comprises hydrogenating a sulfonic acid salt of formula II,. or a solvate thereof; in the presence of a solvent system consisting essentially of water, a C3-5 secondary alkyl alcohol and no more than 15% v/v of another organic solvent, wherein the sulfonic acid salt of formula I is optionally, without isolation, converted to a compound of formula IX, or a pharmaceutically-acceptable derivative thereof, wherein R1, R2, R3, R6, R7, R8, A, B and D have meanings given in the description.
New oxabispidine compounds for the treatment of cardiac arrhythmias
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Page/Page column 76; 77-78, (2008/06/13)
There is provided compounds of formula I, wherein R1, R2, R3, R41 to R46, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
