1477511-05-9Relevant articles and documents
Stereoselective synthesis of P-modified α-glycosyl phosphates by the oxazaphospholidine approach
Noro, Mihoko,Fujita, Shoichi,Wada, Takeshi
supporting information, p. 5948 - 5951 (2014/01/06)
α-Glycosyl phosphate derivatives are widely known as constituents of biomolecules. To date, several types of non-natural α-glycosyl phosphates including P-modified analogs have been synthesized to investigate their characteristics. Herein a new approach to the stereoselective modification of the intersugar phosphorus atom in α-glycosyl phosphates by use of the oxazaphospholidine method is presented. Via this approach, the dimers of α-glycosyl phosphorothioates and α-glycosyl boranophosphates were obtained efficiently and stereoselectively.