147752-42-9Relevant academic research and scientific papers
Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria
Luo, Jia Lin,Jin, Terry,Váradi, Linda,Perry, John D.,Hibbs, David E.,Groundwater, Paul W.
, p. 15 - 26 (2015/10/29)
New fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfonamides or 6-hydrazinobenz[de]isoquinoline-1,3-diones with β-alanine. The 6-hydrazinobenz[de]isoquinoline-1,3-diones were also condensed with a range of aryl aldehydes to give the corresponding hydrazones. The photophysical properties of the synthesized amines and hydrazines and their amide, hydrazide and hydrazone derivatives, were examined and they were also incorporated into Columbia agar in order to determine their potential for the detection of pathogenic bacteria.
Caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors
Xu, Yu-Wen,Zhao, Gui-Sen,Shin, Cha-Gyun,Zang, Heng-Chang,Lee, Chong-Kyo,Lee, Yong Sup
, p. 3589 - 3593 (2007/10/03)
HIV-1 integrase (IN) is an essential enzyme for retroviral replication and a rational target for the design of anti-AIDS drugs. In the present study, we have designed, synthesized and tested a series of caffeoyl naphthalenesulfonamide derivatives as HIV integrase inhibitors. Among these compounds, we found that HIV integrase inhibitory activities of compounds III-3 and III-4 were more potent than L-chicoric acid (IC50=11.8 μg/mL) and others were comparable to L-chicoric acid. Furthermore, the structure-activity relationships of these compounds were studied. The information gathered from this paper will be useful in the development and design of HIV-1 integrase inhibitors in the future.
