147805-12-7

Upstream product

• 31380-91-3 4-amino-5-chloro-2-methoxybenzonitrile 
• 24190-74-7 4-amino-5-chloro-2-methoxybenzamide 
• 171351-19-2 1H-1,2,3-benzotriazol-1-yl 4-amino-5-chloro-2-methoxybenzoate 

Downstream Products

• 174822-16-3 2-chloro-5-methoxy-4-<5-(2-piperidylmethyl)-1,2,4-oxadiazol-3-yl>aniline 

Relevant academic research and scientific papers

Synthesis of the selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist (+)-(S)-2-chloro-5-methoxy-4-[5-(2-piperidylmethyl)-1,2,4-oxadiazol- 3-yl]aniline

In a search for novel 5-hydroxytryptamine 4 (5-HT4) agonists focusing on the linker group of benzamide derivatives, 2-chloro-5-methoxy-4-[5-(2- piperidylmethyl)-1,2,4-oxadiazol-3-yl]aniline (2) was prepared and its optical isomers were separate

5-HT4 receptor antagonists

The invention provides the use of a compound of formula (I) STR1 wherein A, E, F, U, X, Y, Z, are as defined in the specification, or a pharmaceutically acceptable salt thereof, for the treatment of diarrhea predominant irritable bowel syndrome.