147807-55-4

Basic information

• Product Name: 4-(4-Methoxy-benzyloxy)-benzoic acid hydrazide
• Synonyms: 4-(4-Methoxy-benzyloxy)-benzoic acid hydrazide
• CAS NO: 147807-55-4
• Molecular Weight: 272.304
• Mol File: 147807-55-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-Methoxy-benzyloxy)-benzoic acid hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methoxy-benzyloxy)-benzoic acid hydrazide(147807-55-4)
• EPA Substance Registry System: 4-(4-Methoxy-benzyloxy)-benzoic acid hydrazide(147807-55-4)

Safety Data

• Hazardous Substances Data: 147807-55-4(Hazardous Substances Data)

Upstream product

• 120-47-8 Ethyl 4-hydroxybenzoate 
• 824-94-2 p-methoxybenzyl chloride 
• 56441-84-0 ethyl 4-((4-methoxybenzyl)oxy)-benzoate 

Downstream Products

• 1630012-56-4 C₁₆H₁₄N₂O₄ 
• 1630012-83-7 C₂₀H₂₅N₃O₄ 
• 1630013-24-9 4-butyl-5-(4-(4-methoxybenzyloxy)phenyl)-2H-1,2,4-triazole-3(4H)-one 
• 147807-62-3 4-(4-Methoxy-benzyloxy)-benzoic acid N'-(2-cyano-ethyl)-hydrazide 

Relevant articles and documents

Synthesis and anticonvulsant activity evaluation of 4-butyl-5-(4- alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones

A series of 4-butyl-5-(4-alkoxyphenyl)-2H-1,2,4-triazole-3(4H)-ones (6a-6u) was designed and synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test. Among the synthetic compounds, 4-butyl-5-(4-(2-fluorinebenzyl)phenyl)-2H-1,2,4- triazole-3 (4H)-one (6k) was the most potent with ED50 value of 27.4 mg/kg and protective index (PI = TD50/ED50) value of 12.0. Besides the anti-MES efficacy, the potency of compound 6k against seizures induced by pentylenetetrazole (PTZ), 3-mercaptopropionic acid (3-MP), and bicuculline (BIC) was also established, which suggested that the mechanisms of action including enhancing of GABAergic activity might be involved in its anticonvulsant activity.