147832-98-2Relevant academic research and scientific papers
Syntheses of Novel 25-Hydroxyvitamin D3 Haptens having Chemical Bridges at the C-11α Position
Kobayashi, Norihiro,Hisada, Akihiko,Shimada, Kazutake
, p. 31 - 38 (2007/10/02)
The serum or plasma levels of 25-hydroxyvitamin D3 1a is useful for the evaluation of vitamin D status in various clinical or nutritional disorders.To obtain antibodies to compound 1a which are highly specific and useful for development of immunoassays, two novel haptenic derivatives, 11α-(3-carboxypropionyloxy)-25-hydroxyvitamin D3 2a and 11α-(4-carboxybutyryloxy)-25-hydroxyvitamin D3 2b were synthesized each in 21 steps from 11α-hydroxydehydroepiandrosterone 3.
