147837-52-3

Basic information

• Product Name: AC-VAD-CHO
• Synonyms: N-acetyl-Val-Ala-Asp-Ala;Acetyl-valyl-alanyl-aspartal;N-Acetyl-Val-Ala-Asp-al (AC-VAD-CHO);AC-VAD-CHO;AC-VAL-ALA-ASP-ALDEHYDE;AC-VAL-ALA-ASP-ALDEHYDE (PSEUDO ACID);AC-VAL-ALA-ASP-CHO;CASPASE INHIBITOR II
• CAS NO: 147837-52-3
• Molecular Formula: C14H23N3O6
• Molecular Weight: 329.35
• Product Categories: Dipeptides and Tripeptides;Peptides;Tripeptides;Dipeptides and Tripeptides;Aldehydes;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Pepetides
• Mol File: 147837-52-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 698.2 °C at 760 mmHg
• Flash Point: 376 °C
• Appearance: /
• Density: 1.215 g/cm³
• Vapor Pressure: 2.43E-21mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: −20°C
• CAS DataBase Reference: AC-VAD-CHO(CAS DataBase Reference)
• NIST Chemistry Reference: AC-VAD-CHO(147837-52-3)
• EPA Substance Registry System: AC-VAD-CHO(147837-52-3)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 147837-52-3(Hazardous Substances Data)

Usage

General Description

AC-VAD-CHO is a chemical compound that is commonly used as a caspase inhibitor in biochemical and pharmacological research. It is an aldehyde-containing inhibitor of caspase-1, caspase-4, caspase-5, caspase-7, caspase-8, and caspase-10. AC-VAD-CHO works by irreversibly binding to the active site of the caspase enzyme, thereby preventing the enzyme from cleaving its substrate and halting the apoptotic process. Additionally, AC-VAD-CHO is often used to study the role of caspases in cell death pathways and to develop potential therapeutic strategies for conditions such as cancer and neurodegenerative diseases.

InChI:InChI=1/C14H23N3O6/c1-7(2)12(16-9(4)19)14(23)15-8(3)13(22)17-10(6-18)5-11(20)21/h6-8,10,12H,5H2,1-4H3,(H,15,23)(H,16,19)(H,17,22)(H,20,21)/t8-,10-,12-/m0/s1

Relevant articles and documents

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