147849-82-9

Basic information

• Product Name: 6-(tert-butyl)pyridazin-3(2H)-one
• Synonyms: 6-(tert-butyl)pyridazin-3(2H)-one;6-tert-butyl-2,3-dihydropyridazin-3-one
• CAS NO: 147849-82-9
• Molecular Formula: C8H12N2O
• Molecular Weight: 152.19
• Mol File: 147849-82-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.07±0.1 g/cm3(Predicted)
• PKA: 11.51±0.40(Predicted)
• CAS DataBase Reference: 6-(tert-butyl)pyridazin-3(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(tert-butyl)pyridazin-3(2H)-one(147849-82-9)
• EPA Substance Registry System: 6-(tert-butyl)pyridazin-3(2H)-one(147849-82-9)

Safety Data

• Hazardous Substances Data: 147849-82-9(Hazardous Substances Data)

Usage

General Description

6-(tert-butyl)pyridazin-3(2H)-one is a chemical compound with the molecular formula C9H14N2O. It is a heterocyclic compound containing a pyridazine ring substituted with a tert-butyl group at the 6-position and a ketone functional group at the 3-position. 6-(tert-butyl)pyridazin-3(2H)-one is used in various research and industrial applications, including as a building block in organic synthesis and as a ligand in coordination chemistry. It may also have potential pharmaceutical applications, although further research is needed to fully understand its properties and potential uses.

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 1046816-36-7 6-tert-butyl-4,5-dihydropyridazin-3(2H)-one 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 1086383-74-5 3-bromo-6-tert-butylpyridazine 
• 41144-46-1 3-chloro-6-(1,1-dimethylethyl)pyridazine 

Relevant articles and documents

Bulk Inclusions of Double Pyridazine Molecular Rotors in Hexagonal Tris(o-phenylene)cyclotriphosphazene

A new generation of double pyridazine molecular rotors differing in intramolecular dipole-dipole spacing was synthesized. All rotor molecules formed bulk inclusions in a tris(o-phenylenedioxy)cyclotriphosphazene (TPP) host. Results of dielectric spectroscopy were fitted to a pair of nine-state models that accounted for interactions of neighboring dipoles at either an aligned or opposed possible orientation of the local threefold dipole rotation potentials within a channel of the TPP host. The results indicate dipole-dipole interaction strengths at the 100 to 200 K scale that lead dipoles to preferentially populate a subset of low-energy configurations. They also reveal that pyridazines with ethynyl substituents in 3- and 6-positions have slightly higher rotational barriers (3.2-3.5 kcal/mol) than those carrying one ethynyl and one tert-butyl group (1.9-3.0 kcal/mol). Upon cooling, these barriers reduce the rate of thermal transitions between the potential wells so much that the inclusions cannot achieve ordered dipolar ground states.

Endothelin receptor antagonists

This invention relates to pyridizinone derivatives of formula I STR1 wherein the various substituents are defined in the specification, and salts thereof, which have useful pharmacological properties, in particular endothelin receptor-antagonistic properties. The compounds are thus useful for the treatment of illnesses associated with endothelin activities, such as hypertension, cardiac insufficiency, coronary heart disease, renal, cerebral and myocardial ischaemia, renal insufficiency, cerebral infarct, subarachnoid haemorrhage, arteriosclerosis pulmonary high blood pressure, inflammations, asthma, prostate hyperplasia, endotoxic shock and in complications after the administration of immunosuppressants which produce renal vasoconstriction.