1478642-79-3Relevant academic research and scientific papers
One-pot three-component barbier-type reaction for the synthesis of β-nitroamines
Soengas, Raquel G.,Silva, Artur M. S.
, p. 1949 - 1952 (2013)
The combination of an aldehyde, bromonitromethane, and p-methoxyaniline in the presence of tin(II) chloride and titanium tetraethoxide allows a straightforward access to β-nitroamine derivatives. The use of solid paraformaldehyde results in the amino methylation of methylnitronate. On the other hand, chiral sugar-derived aldehydes furnished the corresponding nitrosugars in high yields and stereoselectivities.
An unusual 1,2-aryl shift in palladium-catalyzed cross-coupling ethoxycarbonylation of arylboronic acids with α-iminoesters
Qian, Cheng,Chen, Jiayan,Fu, Meiqin,Zhu, Shiya,Chen, Wen-Hua,Jiang, Huanfeng,Zeng, Wei
, p. 6013 - 6022 (2013/09/12)
The Pd-catalyzed cross-coupling ethoxycarbonylation of aryl boronic acids with N-aryl-α-iminoesters affords aryl carboxylic esters via carbonyl-imino σ bond cleavage. This unprecedented mode of reaction allows regioselective installation of the ethoxycarbonyl group into target molecules. Mechanism studies have revealed that an unusual 1,2-aryl shift process is involved in the transformation. The Royal Society of Chemistry.
