1478862-48-4Relevant academic research and scientific papers
New synthetic approach to coumarino[4,3-b]pyridine systems and potential cytotoxic evaluation
Hamama, Wafaa S.,Ibrahim, Mona E.,Metwalli, Asmaa E.,Zoorob, Hanafi H.
, p. 2615 - 2621 (2014/05/06)
The reaction of 4-aminocoumarin (2) with appropriate α,β- unsaturated ketones gave the corresponding coumarin [4,3- b]pyridines. Thus, treatment of 2 with ( E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one, (1 E,4E)-1,5-diphenylpenta-1,4-dien-3-one, (Z)-ethyl 3-(4-chloro-phenyl)-2- cyanoacrylate, and (2E,6E)-2,6-dibenzylidenecyclohexanone (3, 6 and 12) afforded the corresponding coumarino[4,3-b]pyridines 5, 7 and coumarino[4,3-b] quinoline derivatives 13, respectively. Heterocyclic annulations of coumarino [5,4- b]pyridine system were achieved via reaction of 2 (in situ) with benzylidene derivatives of indandione to give 15 which was also obtained by multicomponent condensation reaction of 2 (in situ) with indandione and benzaldehyde. A representative sample of new synthesized compounds was evaluated as cytotoxic agents. Springer Science+Business Media 2013.
