1478881-72-9Relevant academic research and scientific papers
POLYSUBSTITUTED ARENES AND SYNTHESIS THEREOF
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Paragraph 0047; 0048; 0049, (2015/11/30)
A compound having general formula (I) wherein, R1 and R2 are, independently of each other, CN or NH2, or together form a substituted aromatic ring system or an unsubstituted aromatic ring system. R3 and R4
Fluorinated alkynylphosphonates in C,C-cyclizations: Regioselective formation of polysubstituted fluorinated arylphosphonates
Duda, Blazej,Tverdomed, Sergey N.,Ionin, Boris I.,Roeschenthaler, Gerd-Volker
supporting information, p. 3757 - 3761 (2014/06/24)
The regioselective C,C-cyclization of selected 1,4-bipolar substrates with fluorinated alkynylphosphonates provided polysubstituted benzenes and naphthalenes in up to 98-% yield. For the case in which tetraethyl ethynylbisphosphonate was used, an unexpected phosphonate-phosphoramidate rearrangement was, for the first time, observed, which occurred in excellent yield. A regioselective synthetic approach towards polysubstituted benzenes and naphthalenes containing a phosphonate and fluorinated groups at the ortho position to each other is reported. By using mild reaction conditions such as K2CO3 as the base in refluxing toluene, the target arenes can be isolated in up to 95-% yield within only 10-12 h. Copyright
