1479084-85-9Relevant articles and documents
Discovery of highly potent, selective, and brain-penetrant aminopyrazole Leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors
Estrada, Anthony A.,Chan, Bryan K.,Baker-Glenn, Charles,Beresford, Alan,Burdick, Daniel J.,Chambers, Mark,Chen, Huifen,Dominguez, Sara L.,Dotson, Jennafer,Drummond, Jason,Flagella, Michael,Fuji, Reina,Gill, Andrew,Halladay, Jason,Harris, Seth F.,Heffron, Timothy P.,Kleinheinz, Tracy,Lee, Donna W.,Pichon, Claire E. Le,Liu, Xingrong,Lyssikatos, Joseph P.,Medhurst, Andrew D.,Moffat, John G.,Nash, Kevin,Scearce-Levie, Kimberly,Sheng, Zejuan,Shore, Daniel G.,Wong, Susan,Zhang, Shuo,Zhang, Xiaolin,Zhu, Haitao,Sweeney, Zachary K.
, p. 921 - 936 (2014/03/21)
Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for a potential disease-modifying Parkinson's disease therapy. Herein, we disclose structurally div
