147912-69-4

Upstream product

• 147912-64-9 methyl 2--3-<2-bromo-4,5-(methylenedioxy)phenyl>propanoate 
• 227286-90-0 methyl (S)-2--3-<2-bromo-4,5-(methylenedioxy)phenyl>propanoate 
• 5434-47-9 5-bromo-6-bromomethylbenzo[1,3]dioxole 
• 227286-96-6 methyl (S)-2--3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate 
• 227286-89-7 methyl (S)-3-<3,4-(methylenedioxy)phenyl>-2-propanoate 
• 161392-59-2 methyl (S)-2-amino-3-<3,4-bis(tert-butyldimethylsilyloxy)phenyl>propanoate 
• 1421-65-4 L-dopa methyl ester hydrochloride 
• 55135-66-5 9-bromo-9-phenyl-9H-fluorene 

Downstream Products

• 195193-47-6 6-(9-Phenyl-9H-fluoren-9-ylamino)-6,7-dihydro-indeno[5,6-d][1,3]dioxol-5-one 
• 147912-74-1 3-(9-phenylfluoren-9-yl)-4-<<2-bromo-4,5-(methylenedioxy)phenyl>methyl>oxazolidin-5-one 

Relevant academic research and scientific papers

Enantiospecific synthesis of (+)-ribasine

The alkaloid (+)-ribasine was synthesized by stereocontrolled addition of substituted α-lithium-o-toluate 6d to enantiomerically pure (R)-N-(9- phenylfluoren-9-yl)-2-amino-5,6-(methylenedioxy)indan-1-one [(+)-5]. Aminoindanone (+)-5 was prepared from amino acid (-)-15 obtained by diastereoselective alkylation of a chiral glyeme enolate synthon.

Synthesis of 2--1-indanones by Anionic Cyclization of Phenylalanine-Derived Oxazolidinones

A novel preparation of N-(phenylfluorenyl)-2-amino-1-indanones is described.The key step is the cyclization of aryl-substituted o-bromophenylalanine-derived oxazolidinones with n-BuLi by halogen-metal exchange followed by in situ intramolecular acylation