147920-40-9Relevant academic research and scientific papers
Synthesis method of alpha-fluorovinyl sulfide derivative
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Paragraph 0013; 0032-0038, (2020/11/22)
The invention relates to a synthesis method of an alpha-fluorovinyl sulfide derivative, which comprises the following steps: by using a trifluoroethyl derivative as a substrate, diphenyl disulfide asa sulfur source, palladium acetate as a catalyst, triphenylphosphine as a ligand, cesium carbonate as an alkali and zinc powder as a reducing agent, carrying out stirring reaction in an N,N-dimethylformamide solvent at 60-100 DEG C in a nitrogen atmosphere for 1-2 hours. Herein, odorless, readily available and cheap diphenyl disulfide is used as a sulfur source, so that the method has the advantages of simple and readily available raw materials, simple reaction operation, relatively mild conditions, wide substrate universality, high yield and good functional group compatibility.
Radical-mediated thiodesulfonylation of the vinyl sulfones: access to (α-fluoro)vinyl sulfides
Sacasa, Pablo R.,Zayas, Jessica,Wnuk, Stanislaw F.
experimental part, p. 5424 - 5427 (2009/12/06)
Radical-mediated thiodesulfonylation of the vinyl and (α-fluoro)vinyl sulfones, derived from aldehydes and ketones, with aryl thiols in organic or aqueous medium provided access to vinyl and (α-fluoro)vinyl sulfides. The vinyl sulfides were formed predominantly with E stereochemistry independent of the stereochemistry of the starting vinyl sulfones.
