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14794-31-1 Usage

Chemical Properties

clear colourless to yellow liquid

Uses

Ethyl 4-chloro-4-oxobutyrate was used in the synthesis of:polymer-supported bifunctional catalystsuccinimidyl ester of benzo(a)pyrenesuccinate prodrugs of curcuminoids

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 14794-31-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,9 and 4 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 14794-31:
(7*1)+(6*4)+(5*7)+(4*9)+(3*4)+(2*3)+(1*1)=121
121 % 10 = 1
So 14794-31-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H9ClO3/c1-2-10-6(9)4-3-5(7)8/h2-4H2,1H3

14794-31-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A12734)  Ethyl succinyl chloride, 97%   

  • 14794-31-1

  • 25g

  • 625.0CNY

  • Detail
  • Alfa Aesar

  • (A12734)  Ethyl succinyl chloride, 97%   

  • 14794-31-1

  • 100g

  • 1736.0CNY

  • Detail
  • Alfa Aesar

  • (A12734)  Ethyl succinyl chloride, 97%   

  • 14794-31-1

  • 500g

  • 6891.0CNY

  • Detail
  • Aldrich

  • (190705)  Ethyl4-chloro-4-oxobutyrate  95%

  • 14794-31-1

  • 190705-25G

  • 655.20CNY

  • Detail
  • Aldrich

  • (190705)  Ethyl4-chloro-4-oxobutyrate  95%

  • 14794-31-1

  • 190705-100G

  • 1,674.27CNY

  • Detail

14794-31-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 3-(chloroformyl)propionate

1.2 Other means of identification

Product number -
Other names ethyl 4-chloro-4-oxobutanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14794-31-1 SDS

14794-31-1Synthetic route

butanedioic acid, monoethyl ester
1070-34-4

butanedioic acid, monoethyl ester

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

Conditions
ConditionsYield
With thionyl chloride In dichloromethane Heating;100%
With thionyl chloride for 1.5h; Heating;97%
With thionyl chloride In dichloromethane; N,N-dimethyl-formamide at 38℃; for 5h; Inert atmosphere;95%
succinic acid anhydride
108-30-5

succinic acid anhydride

ethanol
64-17-5

ethanol

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

Conditions
ConditionsYield
Stage #1: succinic acid anhydride; ethanol for 2h; Reflux;
Stage #2: With thionyl chloride for 2h; Reflux;
82%
With thionyl chloride Yield given. Multistep reaction;
(E)-4-ethoxy-4-oxobut-2-enoic acid
2459-05-4

(E)-4-ethoxy-4-oxobut-2-enoic acid

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

Conditions
ConditionsYield
With thionyl chloride for 5h; Heating;68%
sodium salt of succinic acid monoethyl ester

sodium salt of succinic acid monoethyl ester

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

Conditions
ConditionsYield
With trichlorophosphate
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60 percent / KOH / ethanol / 16 h / 0 °C
2: 97 percent / SOCl2 / 1.5 h / Heating
View Scheme
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

ethyl cinnamate
4192-77-2

ethyl cinnamate

diethyl 4-oxo-3-phenylheptane-1,7-dioate

diethyl 4-oxo-3-phenylheptane-1,7-dioate

Conditions
ConditionsYield
With magnesium In N,N-dimethyl-formamide at 20℃; for 15h;100%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

amonafide
69408-81-7

amonafide

ethyl 4-N-[{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl}amino]-4-oxobutanoate

ethyl 4-N-[{2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl}amino]-4-oxobutanoate

Conditions
ConditionsYield
In acetonitrile at 20℃; for 1h;100%
In acetonitrile at 20℃; for 1h;100%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

2,6-di-tert-butyl-4-{4-[3,5-di-tert-butyl-4-(4-hydroxybutoxy)phenylsulfanyl]piperidin-4-ylsulfanyl}phenol
1402049-46-0

2,6-di-tert-butyl-4-{4-[3,5-di-tert-butyl-4-(4-hydroxybutoxy)phenylsulfanyl]piperidin-4-ylsulfanyl}phenol

4-[4-[3,5-di-tert-butyl-4-(4-hydroxybutoxy)phenylsulfanyl]-4-(3,5-di-tert-butyl-4-hydroxyphenyl-sulfanyl)piperidin-1-yl]-4-oxobutyric acid ethyl ester
1402049-48-2

4-[4-[3,5-di-tert-butyl-4-(4-hydroxybutoxy)phenylsulfanyl]-4-(3,5-di-tert-butyl-4-hydroxyphenyl-sulfanyl)piperidin-1-yl]-4-oxobutyric acid ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; for 0.25h;100%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

diazomethyl-trimethyl-silane
18107-18-1

diazomethyl-trimethyl-silane

ethyl 5-bromo-4-oxopentanoate
14594-25-3

ethyl 5-bromo-4-oxopentanoate

Conditions
ConditionsYield
Stage #1: ethyl 3-(chloroformyl)propionate; diazomethyl-trimethyl-silane In diethyl ether; acetonitrile at 20℃; for 1h;
Stage #2: With hydrogen bromide In diethyl ether; acetic acid; acetonitrile at -20 - 20℃; for 16.33h;
99%
Stage #1: ethyl 3-(chloroformyl)propionate; diazomethyl-trimethyl-silane In hexane; acetonitrile for 2h;
Stage #2: With hydrogen bromide; acetic acid In hexane; acetonitrile for 1h;
64%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

methyl 2-amino-5-iodobenzoate
77317-55-6

methyl 2-amino-5-iodobenzoate

2-(3-ethoxycarbonyl-propionylamino)-5-iodo-benzoic acid methyl ester
884196-07-0

2-(3-ethoxycarbonyl-propionylamino)-5-iodo-benzoic acid methyl ester

Conditions
ConditionsYield
With dmap; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;99%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride
101403-24-1

(S)-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-propylamine hydrochloride

(S)-ethyl 4-((5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)-4-oxobutanoate
1403822-87-6

(S)-ethyl 4-((5-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)-4-oxobutanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 3h;99%
4-hydroxy-2,5-diphenyl-1,3-thiazole
59484-42-3

4-hydroxy-2,5-diphenyl-1,3-thiazole

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

2,5-diphenyl-4-<(ethyloxysuccinyl)oxy>thiazole
131786-91-9

2,5-diphenyl-4-<(ethyloxysuccinyl)oxy>thiazole

Conditions
ConditionsYield
With dmap In dichloromethane at 23℃; for 2h;97%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(1,4-phenylene) diethyl disuccinate

4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(1,4-phenylene) diethyl disuccinate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;97%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

(tert-Butoxycarbonylmethylene)triphenylphosphorane
86302-43-4

(tert-Butoxycarbonylmethylene)triphenylphosphorane

t-butyl 5-ethoxycarbonyl-3-oxo-2-(triphenylphosphoranylidine)-pentanoate
123475-42-3

t-butyl 5-ethoxycarbonyl-3-oxo-2-(triphenylphosphoranylidine)-pentanoate

Conditions
ConditionsYield
In benzene96%
In benzene at 8 - 20℃; for 1.5h;87%
In benzene 1.) 8 deg C, 5 min, 2.) r.t., 1.5 h;87%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

2-carboethoxy-4,5-dimethoxyaniline
20323-74-4

2-carboethoxy-4,5-dimethoxyaniline

4,5-dimethoxy-2-[(4-ethoxy-1,4-dioxobutyl)amino]benzoic acid ethyl ester
380396-37-2

4,5-dimethoxy-2-[(4-ethoxy-1,4-dioxobutyl)amino]benzoic acid ethyl ester

Conditions
ConditionsYield
With pyridine In tetrahydrofuran at 20℃; for 2h;96%
With pyridine In toluene at 20℃; for 4h;70%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

4-((1E,6E)-7-(4-(4-ethoxy-4-oxobutanoyloxy)-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)phenyl ethyl succinate

4-((1E,6E)-7-(4-(4-ethoxy-4-oxobutanoyloxy)-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)phenyl ethyl succinate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;96%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

C13H10BrNO

C13H10BrNO

C19H18BrNO4

C19H18BrNO4

Conditions
ConditionsYield
In dichloromethane at 60℃; for 1h;96%
With sodium hydroxide In dichloromethane at 60℃; for 1h;96%
pyrrolidine
123-75-1

pyrrolidine

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

C10H17NO3

C10H17NO3

Conditions
ConditionsYield
Stage #1: pyrrolidine With triethylamine In dichloromethane at 0℃; for 0.25h; Inert atmosphere;
Stage #2: ethyl 3-(chloroformyl)propionate In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;
96%
With triethylamine In dichloromethane at 0 - 20℃; for 1h; Inert atmosphere;96%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl
14691-88-4

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl

A

triethylamine hydrochloride
554-68-7

triethylamine hydrochloride

B

C15H27N2O4
82032-23-3

C15H27N2O4

Conditions
ConditionsYield
With triethylamine In benzene 1.) 0 degC, 2.) R.T. 12 h;A n/a
B 95%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

curcumin
458-37-7

curcumin

4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene) diethyl disuccinate

4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene) diethyl disuccinate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;95%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

n-octylmagnesium chloride
38841-98-4

n-octylmagnesium chloride

4-Oxododecansaeure-ethylester
59941-35-4

4-Oxododecansaeure-ethylester

Conditions
ConditionsYield
With copper(l) iodide In tetrahydrofuran at 0 - 20℃;95%
With copper(l) iodide In tetrahydrofuran at 0 - 20℃; for 3h; Inert atmosphere;
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

1,6,8-trihydroxy-3-methyl-9,10-anthraquinone
518-82-1

1,6,8-trihydroxy-3-methyl-9,10-anthraquinone

1,8-dihydroxy-6-methyl-9,10-anthraquinone-3-oxy ethyl succinate

1,8-dihydroxy-6-methyl-9,10-anthraquinone-3-oxy ethyl succinate

Conditions
ConditionsYield
With pyridine In dichloromethane at 0 - 20℃; for 3h;94.7%
tryptamine
61-54-1

tryptamine

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

ethyl 4-{[2-(1H-Indol-3-yl)ethyl]amino}-4-oxobutanoate
1157-57-9

ethyl 4-{[2-(1H-Indol-3-yl)ethyl]amino}-4-oxobutanoate

Conditions
ConditionsYield
Stage #1: ethyl 3-(chloroformyl)propionate With triethylamine In dichloromethane at 20℃;
Stage #2: tryptamine In methanol; chloroform at 20℃;
94%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

1,1-dimethylethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate
146953-11-9

1,1-dimethylethyl -<2-<<2-amino-3-(1H-indol-3-yl)-2-methyl-1-oxopropyl>amino>-1-phenylethyl>carbamate

ethyl -4-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-4-oxobutanoate
146953-12-0

ethyl -4-<<2-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-2-phenylethyl>amino>-1-(1H-indol-3-ylmethyl)-1-methyl-2-oxoethyl>amino>-4-oxobutanoate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran for 2h; Ambient temperature;93%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

Bis(trimethylsilyl)ethyne
14630-40-1

Bis(trimethylsilyl)ethyne

4-Oxo-6-trimethylsilanyl-hex-5-ynoic acid ethyl ester
178760-79-7

4-Oxo-6-trimethylsilanyl-hex-5-ynoic acid ethyl ester

Conditions
ConditionsYield
With aluminium trichloride In dichloromethane 1) 0 deg C, 15 min, 2) rt, 3 h;93%
With aluminium trichloride In dichloromethane at 0 - 20℃; for 4h; Acylation;
tetrakis-5,10,15,20-(o-aminophenyl)porphyrin
52199-35-6

tetrakis-5,10,15,20-(o-aminophenyl)porphyrin

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

α-5,10,15,20-tetrakis{2-[3-(ethoxycarbonyl)propionylamido]phenyl}porphyrin

α-5,10,15,20-tetrakis{2-[3-(ethoxycarbonyl)propionylamido]phenyl}porphyrin

Conditions
ConditionsYield
Acylation;93%
With triethylamine In tetrahydrofuran at 0℃;93%
thiophene
188290-36-0

thiophene

ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

ethyl 4-oxo-4-(thiophen-2-yl)butanoate
59086-25-8

ethyl 4-oxo-4-(thiophen-2-yl)butanoate

Conditions
ConditionsYield
With tin(IV) chloride In dichloromethane at 20℃; for 2h; Cooling;93%
With tin(IV) chloride In dichloromethane at 20℃; Friedel-Crafts;83%
With tin(IV) chloride In dichloromethane at 0 - 20℃; Friedel Crafts acylation;
With tin(IV) chloride at 20℃; Friedel-Crafts Acylation;
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

L-valylaminooctadecane

L-valylaminooctadecane

N-(2-methyl-1-octadecylcarbamoyl-propyl)-succinamic acid ethyl ester

N-(2-methyl-1-octadecylcarbamoyl-propyl)-succinamic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 12h;93%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

2-aminoacetophenone hydrochloride
5468-37-1

2-aminoacetophenone hydrochloride

N-(3-Carbethoxypropanoyl)-ω-aminoacetophenone
133602-34-3

N-(3-Carbethoxypropanoyl)-ω-aminoacetophenone

Conditions
ConditionsYield
In pyridine at 25℃; for 96h;92%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

1'-(3-aza-spiro[5.5]undecane-9-carbonyl)-[4,4']bipiperidinyl-1-carboxylic acid benzyl ester

1'-(3-aza-spiro[5.5]undecane-9-carbonyl)-[4,4']bipiperidinyl-1-carboxylic acid benzyl ester

1'-[3-(3-ethoxycarbonyl-propionyl)-3-aza-spiro[5.5]undecane-9-carbonyl]-[4,4']bipiperidinyl-1-carboxylic acid benzyl ester
352348-32-4

1'-[3-(3-ethoxycarbonyl-propionyl)-3-aza-spiro[5.5]undecane-9-carbonyl]-[4,4']bipiperidinyl-1-carboxylic acid benzyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dichloromethane92%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

α-5,10,15-tris(2-aminophenyl)-α-20-[2-(acetylamido)phenyl]-porphyrin

α-5,10,15-tris(2-aminophenyl)-α-20-[2-(acetylamido)phenyl]-porphyrin

α-5,10,15-tris{2-[3-(ethoxycarbonyl)propionylamido]phenyl}-α-20-[2-(acetylamido)phenyl]-porphyrin

α-5,10,15-tris{2-[3-(ethoxycarbonyl)propionylamido]phenyl}-α-20-[2-(acetylamido)phenyl]-porphyrin

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃;92%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

8-methoxy-2,3,4,4a,5,9b-hexahydro-1h-indeno[1,2-b]pyridine

8-methoxy-2,3,4,4a,5,9b-hexahydro-1h-indeno[1,2-b]pyridine

ethyl 4-(8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-1-yl)-4-oxobutanoate

ethyl 4-(8-methoxy-2,3,4,4a,5,9b-hexahydro-1H-indeno[1,2-b]pyridin-1-yl)-4-oxobutanoate

Conditions
ConditionsYield
With sodium hydroxide In dichloromethane; water at 0 - 20℃; for 2h;92%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

(2-aminophenyl)-(3-methoxyphenyl)methanone
38824-11-2

(2-aminophenyl)-(3-methoxyphenyl)methanone

C20H21NO5

C20H21NO5

Conditions
ConditionsYield
In dichloromethane at 60℃; for 1h;92%
In dichloromethane at 60℃; for 1h;92%
ethyl 3-(chloroformyl)propionate
14794-31-1

ethyl 3-(chloroformyl)propionate

2-amino-3-methylbenzamide
1885-32-1

2-amino-3-methylbenzamide

2-(1,4-dioxo-4-ethoxybutylamino)-3-methylbenzamide

2-(1,4-dioxo-4-ethoxybutylamino)-3-methylbenzamide

Conditions
ConditionsYield
With pyridine In tetrahydrofuran for 16h;92%
With pyridine In tetrahydrofuran for 16h;92%

14794-31-1Relevant articles and documents

Facile Hetero-Diels-Alder Reaction of α,β-Unsaturated Acyl Cyanides and Enol Ethers: Synthesis of 2-Alkoxy-3,4-dihydro-2H-Pyran-6-carbonitriles

John, Robert A.,Schmid, Vincent,Wyler, Hugo

, p. 600 - 606 (1987)

2-Ethoxy-3,4-dihydro-2H-pyran-6-carbonitriles are obtained in high yield by stereospecific endo-mode cycloadditions of α,β-unsaturated acyl cyanides and ethyl vinyl ether at room temperature.The nitrile group is converted to some other functionalities.

Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis

Lee, Hyo-Jun,Huang, Xiao,Sakaki, Shigeyoshi,Maruoka, Keiji

supporting information, p. 848 - 855 (2021/02/09)

A new bio-inspired approach is reported for amide and peptide synthesis using α-amino esters that possess a potential activating group (PAG) at the ester residue. To activate the ester functionality under mild metal-free conditions, we exploited the facile dearomatization of phenols with hypervalent iodine(iii) reagents. Using a pyridine-hydrogen fluoride complex, highly reactive acyl fluoride intermediates can be successfully generated, thereby allowing for the smooth formation of sterically hindered amides and peptides from bulky amines and α-amino esters, respectively.

The emodin succinyl ester compounds in the preparation of pharmaceutical use in fat

-

Paragraph 0056; 0064; 0070, (2018/07/30)

The invention discloses emodin succinyl ester compounds in the preparation of the use of the drug in the blood, which belongs to the field of medical technology, the emodin succinyl ester compound of the structure shown in formula I (R is C1 - 5 Alkyl). The experiment mixed hyperlipidemia rats pharmacological experiment, confirms that the emodin succinyl ester compound is superior to the emodin, with hypolipidemic effects are prominent, good safety, administration is simple and convenient, cheap price of raw materials are easy, convenient transportation and storage advantages. The invention of the proposed emodin succinyl ester compound in the blood lipid-lowering medicine preparation field will have broad application prospects.

COMPOUND FOR PROMOTING APOPTOSIS OF CANCER CELLS AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USES THEREOF

-

Paragraph 0087, (2016/04/20)

The present invention provides a compound of Formula (I) and a salt thereof, wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C1-C20 alkyl. The compound promotes apoptosis in cancer cell and inhibits its growth. The present invention also provides a pharmaceutical composition which comprises the compound of Formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides a method for production of the pharmaceutical composition used for treating cancer.

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