14794-31-1Relevant articles and documents
Facile Hetero-Diels-Alder Reaction of α,β-Unsaturated Acyl Cyanides and Enol Ethers: Synthesis of 2-Alkoxy-3,4-dihydro-2H-Pyran-6-carbonitriles
John, Robert A.,Schmid, Vincent,Wyler, Hugo
, p. 600 - 606 (1987)
2-Ethoxy-3,4-dihydro-2H-pyran-6-carbonitriles are obtained in high yield by stereospecific endo-mode cycloadditions of α,β-unsaturated acyl cyanides and ethyl vinyl ether at room temperature.The nitrile group is converted to some other functionalities.
Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis
Lee, Hyo-Jun,Huang, Xiao,Sakaki, Shigeyoshi,Maruoka, Keiji
supporting information, p. 848 - 855 (2021/02/09)
A new bio-inspired approach is reported for amide and peptide synthesis using α-amino esters that possess a potential activating group (PAG) at the ester residue. To activate the ester functionality under mild metal-free conditions, we exploited the facile dearomatization of phenols with hypervalent iodine(iii) reagents. Using a pyridine-hydrogen fluoride complex, highly reactive acyl fluoride intermediates can be successfully generated, thereby allowing for the smooth formation of sterically hindered amides and peptides from bulky amines and α-amino esters, respectively.
The emodin succinyl ester compounds in the preparation of pharmaceutical use in fat
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Paragraph 0056; 0064; 0070, (2018/07/30)
The invention discloses emodin succinyl ester compounds in the preparation of the use of the drug in the blood, which belongs to the field of medical technology, the emodin succinyl ester compound of the structure shown in formula I (R is C1 - 5 Alkyl). The experiment mixed hyperlipidemia rats pharmacological experiment, confirms that the emodin succinyl ester compound is superior to the emodin, with hypolipidemic effects are prominent, good safety, administration is simple and convenient, cheap price of raw materials are easy, convenient transportation and storage advantages. The invention of the proposed emodin succinyl ester compound in the blood lipid-lowering medicine preparation field will have broad application prospects.
COMPOUND FOR PROMOTING APOPTOSIS OF CANCER CELLS AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND USES THEREOF
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Paragraph 0087, (2016/04/20)
The present invention provides a compound of Formula (I) and a salt thereof, wherein, m is an integer of 2 to 7, and R is independently at least one selected from the group consisting of hydrogen and C1-C20 alkyl. The compound promotes apoptosis in cancer cell and inhibits its growth. The present invention also provides a pharmaceutical composition which comprises the compound of Formula (I), a salt thereof and a pharmaceutically acceptable carrier. The present invention further provides a method for production of the pharmaceutical composition used for treating cancer.