147958-95-0

Basic information

• Product Name: 1-(Biphenyl-4-carbonyl)-piperidine-4-carboxylic acid
• Synonyms: 1-(Biphenyl-4-carbonyl)-piperidine-4-carboxylic acid;1-([1,1'-biphenyl]-4-carbonyl)piperidine-4-carboxylic acid
• CAS NO: 147958-95-0
• Molecular Formula: C₁₉H₁₉NO₃
• Molecular Weight: 309.35906
• Mol File: 147958-95-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 546.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.227±0.06 g/cm3(Predicted)
• PKA: 4.47±0.20(Predicted)
• CAS DataBase Reference: 1-(Biphenyl-4-carbonyl)-piperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Biphenyl-4-carbonyl)-piperidine-4-carboxylic acid(147958-95-0)
• EPA Substance Registry System: 1-(Biphenyl-4-carbonyl)-piperidine-4-carboxylic acid(147958-95-0)

Safety Data

• Hazardous Substances Data: 147958-95-0(Hazardous Substances Data)

Upstream product

• 498-94-2 isonipecotic acid 
• 14002-51-8 4-biphenyl-carboxylic acid chloride 
• 349621-80-3 methyl 1-(biphenyl-4-ylcarbonyl)piperidine-4-carboxylate 

Downstream Products

• 1234709-72-8 biphenyl-4-yl[4-(1H-imidazo[4,5-c]pyridin-2-yl)piperidin-1-yl]methanone 

Relevant articles and documents

Pharmacophore-based tailoring of biphenyl amide derivatives as selective 5-hydroxytryptamine 2B receptor antagonists

We designed and synthesized a new biphenyl amide-tryptamine hybrid molecule 7 utilizing a pharmacophore-based approach as a 5-HT2B antagonist. The hybrid compound 7 was evaluated for its affinity to a panel of seven 5-HT receptors, demonstrating high selectivity for the 5-HT2B receptor. Functional assays revealed potent antagonism of 5-HT2B by 7 with an IC50 value of 14.1 nM. Moreover, compound 7 possessed a desirable in vitro pharmacokinetic profile and maintained its antagonistic potency in the presence of physiological concentrations of serum proteins. The design approach implemented in this investigation would facilitate the development of a second generation of highly selective and potent 5-HT2B antagonists.