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4-[[4-[Bis(2-chloroethyl)amino]phenoxy]carbonylamino]benzoic acid, also known as bendamustine, is a nitrogen mustard alkylating agent with chemotherapeutic and immunosuppressive activities. It is primarily used in the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). Bendamustine exerts its antitumor effects by alkylating and crosslinking DNA, leading to inhibition of DNA replication and RNA transcription and eventual cell death. It also induces immunogenic cell death, enhancing the immune response against cancer cells. Bendamustine has demonstrated significant efficacy and tolerance in the treatment of various hematological malignancies and is an important option in their management.
Used in Pharmaceutical Industry:
4-[[4-[Bis(2-chloroethyl)amino]phenoxy]carbonylamino]benzoic acid is used as a chemotherapeutic agent for the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL) due to its alkylating and crosslinking effects on DNA, leading to inhibition of DNA replication and RNA transcription and eventual cell death.
4-[[4-[Bis(2-chloroethyl)amino]phenoxy]carbonylamino]benzoic acid is also used as an immunosuppressive agent to enhance the immune response against cancer cells by inducing immunogenic cell death.

148-78-7

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148-78-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 148-78-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 8 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 148-78:
(5*1)+(4*4)+(3*8)+(2*7)+(1*8)=67
67 % 10 = 7
So 148-78-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H18Cl2N2O4/c19-9-11-22(12-10-20)15-5-7-16(8-6-15)26-18(25)21-14-3-1-13(2-4-14)17(23)24/h1-8H,9-12H2,(H,21,25)(H,23,24)

148-78-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-[[4-[bis(2-chloroethyl)amino]phenoxy]carbonylamino]benzoic acid

1.2 Other means of identification

Product number -
Other names N-(p-(Bis(2-chloroethyl)amino)phenyl) p-carboxycarbanilate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:148-78-7 SDS

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