1480-89-3

Usage

Uses

Used in Pharmaceutical Research:
6-Fluoropurine is used as a purine nucleoside phosphorylase inhibitor for its potential role in treating certain types of leukemia and autoimmune diseases. Its inhibitory activity targets key enzymes involved in the metabolism of purine nucleosides, offering a novel approach to managing these conditions.
Used in Antileukemic Therapy:
In the field of oncology, 6-Fluoropurine is utilized as an antileukemic agent, specifically for the treatment of certain leukemias. Its mechanism of action involves the inhibition of purine nucleoside phosphorylase, which can lead to the suppression of leukemic cell growth and proliferation.
Used in Autoimmune Disease Treatment:
6-Fluoropurine is employed as a therapeutic agent for autoimmune diseases, leveraging its inhibitory effects on purine nucleoside phosphorylase to modulate immune responses and potentially alleviate disease symptoms.
Used in Anti-inflammatory and Antiviral Drug Development:
6-Fluoropurine is also being explored for its potential anti-inflammatory and antiviral properties, indicating its broad-spectrum applicability in drug development. Its ability to modulate immune responses and exhibit antiviral activity positions it as a candidate for further research and development in these therapeutic areas.

InChI:InChI=1/C5H3FN4/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H,7,8,9,10)

Upstream product

• 87-42-3 6-chloropurine 
• 13020-83-2 N⁶,N⁶,N⁶-trimethyladeninium chloride 

Downstream Products

• 1545-97-7 9-benzyl-6-fluoro-9H-purine 
• 132194-24-2 6-fluoro-9-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-9H-purine 

Relevant academic research and scientific papers

Reactivity of 6-halopurine analogs with glutathione as a radiotracer for assessing function of multidrug resistance-associated protein 1

6-Bromo-7-[11C]methylpurine is reported to react with glutathione via glutathione S-transferases in the brain and to be converted into a substrate for multidrug resistance-associated protein 1 (MRP1), an efflux pump. The compound with a rapid c

The new convenient synthesis of 6-fluoropurine and its 7-/9-unsubstituted analogues

6-Fluoropurine and its 7-/9-unsubstituted analogues have good biological activity and serve as important pharmaceutical intermediates. This paper describes a new and convenient synthesis of 6-fluoropurine and its 7-/9-unsubstituted analogues, by first replacing the chlorine atoms with trimethylammonio groups through the reaction of 6-chloropurine and its 7-/9-unsubstituted analogues with trimethylamine, and then replacing the trimethylammonio groups with fluorine atoms using safe and cheap TBAF·3H2O as fluorinating agent at room temperature. Compared with reported methods, the new synthesis has milder conditions, shorter reaction times, simpler post-processing and higher (or similar) yields.

Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies

(Chemical Equation Presented) Taming the reagent: The use of anhydrous tetrabutylammonium fluoride (TBAFanh) in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAFanh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.