1480-90-6

Basic information

• Product Name: 2-fluoro-hypoxanthine
• Synonyms: 2-fluoro-hypoxanthine;hypoxanthine, 2-fluoro-;2-fluoro-7H-purin-6-ol;2-fluoro-1,7-dihydro-6H-Purin-6-one
• CAS NO: 1480-90-6
• Molecular Formula: C₅H₃FN₄O
• Molecular Weight: 154.1019232
• EINECS: -0
• Mol File: 1480-90-6.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-fluoro-hypoxanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-hypoxanthine(1480-90-6)
• EPA Substance Registry System: 2-fluoro-hypoxanthine(1480-90-6)

Safety Data

• Hazardous Substances Data: 1480-90-6(Hazardous Substances Data)

Upstream product

• 1904-98-9 2,6-diaminopurine 

Relevant articles and documents

One-Step Synthesis of 2-Fluoroadenine Using Hydrogen Fluoride Pyridine in a Continuous Flow Operation

We report the development of a one-pot synthesis of 2-fluoroadenine from an inexpensive 2,6-diaminopurine starting material using diazonium chemistry in a continuous fashion. Given the sensitivity of this transformation to temperature, we conducted critical experiments to study the exothermicity of the reaction and the heat removal, which were critical for the development of the process. Our goal was to improve the yield and purity of this pharmaceutical intermediate (2-fluoroadenine) and develop a more robust process.