148014-37-3 Usage
Uses
Used in Sun Protection Industry:
Tinosorb S is used as a broad-spectrum UV filter in sunscreen products for its ability to protect the skin against both UVA and UVB radiation. It is valued for its high efficiency in absorbing and dissipating harmful UV rays, thereby preventing skin damage and reducing the risk of skin cancer.
Used in Personal Care Products:
In the personal care industry, Tinosorb S is used as an ingredient in various products, such as moisturizers, lotions, and makeup, to provide additional sun protection and prevent skin damage caused by UV exposure.
Used in Pharmaceutical Industry:
Tinosorb S can also be used in pharmaceutical formulations for topical applications, such as creams and ointments, to offer sun protection and reduce the risk of skin cancer in patients with photosensitive conditions or undergoing phototherapy treatments.
Used in Cosmetic Industry:
In the cosmetic industry, Tinosorb S is utilized in makeup products, such as foundations and powders, to provide sun protection and prevent skin damage from UV exposure while enhancing the appearance of the skin.
Check Digit Verification of cas no
The CAS Registry Mumber 148014-37-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,8,0,1 and 4 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 148014-37:
(8*1)+(7*4)+(6*8)+(5*0)+(4*1)+(3*4)+(2*3)+(1*7)=113
113 % 10 = 3
So 148014-37-3 is a valid CAS Registry Number.
148014-37-3Relevant academic research and scientific papers
Synthesis and phospholipase A2 inhibitory activity of thielocin B3 derivatives.
Teshirogi,Matsutani,Shirahase,Fujii,Yoshida,Tanaka,Ohtani
, p. 5183 - 5191 (2007/10/03)
We prepared several types of derivatives of thielocin B3, a very potent naturally occurring inhibitor for human nonpancreatic secretory PLA2 (sPLA2-II), and conducted a structure-activity relationship study to identify potent sPLA2-II inhibitors with the aim of developing antiinflammatory drugs. The total number of aromatic rings is critical for sPLA2-II inhibition, and the best result was obtained in the case of six rings. The structure of the central part of the inhibitors was not specific, and potent inhibitors were found among the sulfide, sulfone, ether, methylene, and amino derivatives. Although a diester of the terminal carboxylic acid lost its inhibitory activity, having both of the carboxylic acids was not necessary for expression of activity, as illustrated by a glycine derivative with the benzyl ester group 36. Among the newly synthesized derivatives, 18, 20, 29, and 36 showed very potent human sPLA2-II inhibitory activity comparable to that of natural thielocin B3. Their IC50 values are in the range 0.069-0.14 microM, and they are a class of compounds showing the most potent sPLA2-II inhibition to date.
