14804-41-2

Upstream product

• 2432-03-3 4-bromopropofol 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 16221-02-6 2,6-Diisopropyl-4-(o-isopropylphenoxy)-anisole 
• 715-71-9 4-fluoro-2,6-diisopropylanisole 
• 13860-74-7 3..3'.5'-Triisopropyl-DL-thyronin 
• 16221-03-7 Ethyl-acetamido<4-(3.5-diisopropyl-4-methoxyphenoxy)-3-isopropylbenzyl>malonat 
• 153742-21-3 diethyl 2-(3,5-diisopropyl-4-methoxyphenyl)malonate 
• 153742-22-4 dimethyl 2-(3,5-diisopropyl-4-methoxyphenyl) malonate 
• 152268-84-3 Adamantan-1-yl-(2'-bromo-3,5,3',5'-tetraisopropyl-4,4'-dimethoxy-biphenyl-2-ylethynyl)-fluoro-(2,4,6-tri-tert-butyl-phenyl)-silane 

Relevant academic research and scientific papers

Synthesis, structure and catalytic properties of new half-titanocene complexes bearing substituted cyclopentadienyl and aryloxide ligands

New cyclopentadienyltitanium aryloxide complexes, 1-phenyl-2,3,4,5- Me4CpTi(O-2,6-iPr2-4-nBu-C6H2)Cl2 (1) and [4,4′-biphenyl-(2,3,4,5-Me4Cp)2][Ti(O-2,6-iPr2-4- nBu-C6H2)Cl2]2 (2), have been prepared by treatment

A 2, 6 - diisopropyl - 4 - fluoro phenol preparation method

The invention discloses a preparation method of 2,6-diisopropyl-4-fluorophenol or a salt thereof, a crystal form of the 2,6-diisopropyl-4-fluorophenol, a medicine composition using the compound as an active ingredient, and an application thereof. The 2,6-

11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia

This invention provides compounds of Formula I having the structure wherein A is hydrogen, halogen, or OH; B and D are each, independently, hydrogen, halogen, CN, alkyl of 1-6 carbon atoms, aryl, aralkyl of 6-12 carbon atoms, nitro, amino or OR; R is hydrogen, alkyl of 1-6 carbon atoms, -COR1, -CH2CO2R1, -CH(R1a)CO2R1, or -SO2R1; R1 and R1a are each, independently, hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms or aryl; E is S, SO, SO2, O; X is hydrogen, halogen, alkyl of 1-6 carbon atoms, CN, perfluoroalkyl of 1-6 carbon atoms, alkoxy of 1-6 carbon atoms, aryloxy, arylalkoxy of 6-12 carbon atoms, nitro, amino, alkylsulfanyl of 1-6 carbon atoms, arylsulfanyl, pyridylsulfanyl, 2-N,N-dimethylaminoethylsulfanyl, or -OCH2CO2R1b; R1b is hydrogen or alkyl of 1-6 carbon atoms; Y and Z are each, independently, hydrogen or OR2; R2 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl of 6-12 carbon atoms, or -CH2CO2R3; R3 is hydrogen or alkyl of 1-6 carbon atoms; C is hydrogen, halogen or OR4; R4 is hydrogen, alkyl of 1-6 carbon atoms, -CH(R5)W, -C(CH3)2CO2R6, 5-thiazolidine-2,4-dione, -CH(R7)CH2CO2R6, -COR6, PO3(R6)2, or -SO2R6; R5 is hydrogen, alkyl of 1-6 carbon atoms, aralkyl, aryl, CH2(1H-imidazol-4-yl), -CH2(3-1H-indolyl), -CH2CH2(1,3-dioxo-1,3-dihydro-isoindol-2-yl), -CH2CH2(1-oxo-1,3-dihydro-isoindol-2-yl), -CH2(3-pyridyl), or -CH2CO2H; W is -CO2R6, -CONH2, -CONHOH, CN, -CONH(CH2)2CN, 5-tetrazole, -PO3(R6)2, -CH2OH, or -CH2Br, -CONR6CHR7CO2R8, R6 is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; R7 is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; R8 is hydrogen, alkyl of 1-6 carbon atoms, aryl or aralkyl; or a pharmaceutically acceptable salt thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia.

Enzymes in organic synthesis 51. Probing the dimensions of the large hydrophobic pocket of the active site of pig liver esterase

The dimensions of the large hydrophobic pocket (H(L)) of the active site model of pig liver esterase (PLE) were probed using a series of aliphatic and phenylic malonates. Results from the hydrolyses of these new unnatural substrates permitted the extension of the H(L) pocket to give the new dimensions of 6.2 x 2.3 x 3.9 A for a total volume of ~56 A3.