148054-86-8

Basic information

• Product Name: (S)-2-Amino-N-(2-dimethylamino-ethyl)-N-methyl-2-phenyl-acetamide
• Synonyms: (S)-2-Amino-N-(2-dimethylamino-ethyl)-N-methyl-2-phenyl-acetamide
• CAS NO: 148054-86-8
• Molecular Weight: 235.329
• Mol File: 148054-86-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-Amino-N-(2-dimethylamino-ethyl)-N-methyl-2-phenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-Amino-N-(2-dimethylamino-ethyl)-N-methyl-2-phenyl-acetamide(148054-86-8)
• EPA Substance Registry System: (S)-2-Amino-N-(2-dimethylamino-ethyl)-N-methyl-2-phenyl-acetamide(148054-86-8)

Safety Data

• Hazardous Substances Data: 148054-86-8(Hazardous Substances Data)

Upstream product

• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 

Downstream Products

• 148054-88-0 ({(S)-2-[(2-Dimethylamino-ethyl)-methyl-amino]-1-phenyl-ethylcarbamoyl}-methyl)-methyl-carbamic acid benzyl ester 
• 148054-71-1 (S)-N²-methyl-N²-(N,N-dimethyl-2-aminoethyl)-1-phenyl-1,2-ethanediamine 

Relevant articles and documents

Enantioselective conjugate addition to cyclic enones with scalemic lithium organo(amido)cuprates, part IV. Relationship between ligand structure and enantioselectivity

Scalemic lithium amides derived from primary and secondary amines react with organocopper compounds in ether or dimethyl sulfide to form lithium organo(amido)cuprates capable of enantioselective conjugate addition to 2-cycloalkenones. The most successful heterocuprate, in which the chiral ligand is (S)-N-methyl-1-phenyl-2-(1-piperidinyl)ethanamine, (S)-MAPP, 13, reacts with cyclic enones to form products with up to 97% ee. Nonlinear asymmetric induction was observed with the cuprate formed from ligand 13.