148076-28-2

Upstream product

• 889864-59-9 (S)-2-Amino-2-phenyl-1-piperidin-1-yl-ethanone 
• 136412-37-8 ((S)-2-Oxo-1-phenyl-2-piperidin-1-yl-ethyl)-carbamic acid benzyl ester 
• 5491-18-9 (S)-N-(benzyloxycarbonyl)phenylglycine 
• 110-89-4 piperidine 
• 39608-31-6 N-(Benzyloxycarbonyl)sarcosine 
• 148054-65-3 (S)-(+)-1-(2-amino-2-phenylethyl)piperidine 

Relevant academic research and scientific papers

Enantioselective conjugate addition to cyclic enones with scalemic lithium organo(amido)cuprates, part IV. Relationship between ligand structure and enantioselectivity

Scalemic lithium amides derived from primary and secondary amines react with organocopper compounds in ether or dimethyl sulfide to form lithium organo(amido)cuprates capable of enantioselective conjugate addition to 2-cycloalkenones. The most successful heterocuprate, in which the chiral ligand is (S)-N-methyl-1-phenyl-2-(1-piperidinyl)ethanamine, (S)-MAPP, 13, reacts with cyclic enones to form products with up to 97% ee. Nonlinear asymmetric induction was observed with the cuprate formed from ligand 13.