148081-73-6Relevant articles and documents
Inhibitory effects of (4-alkoxy-2, 3, 6-trimethylphenyl) glycopyranosides on histamine release induced by antigen-antibody reaction
Wang,Kakegawa,Nakaishi,Matsumoto,Satoh
, p. 1002 - 1004 (1994)
The inhibitory effects of newely synthesized 4-alkoxy-2, 3, 6-trimethylphenyl D-glycopyranosides on histamine release induced by antigen-antibody reaction were examined. Among the compounds tested, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, 4-hexoxy-2, 3, 6-trimethylphenyl α-D-glucopyranoside and α-D-galactopyranoside markedly inhibited antigen-induced histamine release, and their activities were more potent than those of the corresponding β-anomers. These results suggest that these compounds may possess excellent anti-allergic activities.
Synthesis of 4-alkoxyaryl β-D-glucopyranosides and their inhibitory effects on histamine release from rat peritoneal mast cells induced by concanavalin A
Wang,Furukawa,Nihro,Kakegawa,Matsumoto,Satoh
, p. 570 - 575 (2007/10/02)
The inhibitory effects of newly synthesized 4-alkoxyaryl β-D- glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4- decyloxy-2,3,6-trimethylphenyl β-D-glucopyranoside was the most potent inhibitor among the tested compounds.