148119-36-2

Usage

Uses

Used in Medicinal Chemistry:
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(2-methoxyphenyl)-2-propenylidene]is used as a compound in medicinal chemistry for its potential biological activities and structural features that may contribute to the development of new pharmaceuticals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-[3-(2-methoxyphenyl)-2-propenylidene]is used as a starting material or intermediate in the synthesis of drugs, leveraging its unique chemical structure to create novel therapeutic agents.

InChI:InChI=1/C14H12N2O4/c1-20-11-8-3-2-5-9(11)6-4-7-10-12(17)15-14(19)16-13(10)18/h2-8H,1H3,(H2,15,16,17,18,19)/b6-4+

Upstream product

• 67-52-7 BARBITURIC ACID 
• 1504-74-1 2-methoxycinnamaldehyde 
• 60125-24-8 (E)-3-(2-methoxyphenyl)propenal 

Relevant academic research and scientific papers

SHIKIMATE PATHWAY INHIBITORS AND THE USE THEREOF

The present invention relates to methods of inhibiting shikimate pathway, comprising administering to a subject a pharmaceutically acceptable composition comprising a compound having a formula: or pharmaceutically acceptable salts thereof. The present invention also provides a synergistic antibacterial composition containing compound

Mono C-alkylation and mono C-benzylation of barbituric acids through zinc/acid reduction of acyl, benzylidene, and alkylidene barbiturate intermediates

Through systematic exploration of reaction conditions, very efficient preparative procedures for obtaining large quantities of substituted 5-alkyl and 5-benzylbarbituric acids were developed. The procedure involves a two step preparation in which the second step is zinc dust/acid reduction. For preparation of 5-alkylbarbiturates, the first step is the preparation of either 5-acyl or 5-alkylidenebarbiturate. If 5-benzylbarbiturate is the target product, then the first step includes the preparation of 5-benzylidene. Regardless of the nature of the first step, all reactions presented synthetic yields around 90% and isolation and purification involves only crystallization.

Molecular recognition on functionalized self-assembled monolayers of alkanethiols on gold

A system for probing molecular recognition events at organic interfaces using fluorescent receptors is described. Receptors formed from the bis(2,6- diaminopyridine) amide of isophthalic acid are incorporated in mixed self- assembled monolayers (SAMs) of

CHLOROSULFONATION OF 5,5-DIPHENYLHYDANTOIN AND 5-ARYLIDENEBARBITURIC ACIDS

5,5-Diphenylhydantoin (1) by heating with chlorosulfonic acid gave a bis-sulfonyl chloride (2) in which the orientation of sulfonation is apparently meta/para.The chloride (2) was converted into 8 sulfonamides (3-10).Barbituric acid has been condensed with aromatic aldehydes to yield 18 5-arylidene derivatives (11-28).The reaction of chlorosulfonic acid with 5-benzylidenebarbituric acid (11) is discussed together with the subsequent reaction of the sulfonyl chloride with amines.The chlorosulfonation of other arylidenebarbituric acids (12-14, 22, 23, 26 and 28) has also been examined. Key words: 5,5-Diphenylhydantoin; 5-arylidenebarbituric acids; chlorosulfonation; sulfonamides; Michael addition.