148121-24-8

Upstream product

• 33069-62-4 taxol 
• 98-88-4 benzoyl chloride 
• 149705-85-1 7-deoxypaclitaxel 
• 151672-49-0 C₅₄H₇₃NO₁₄S₂Si 
• 151672-48-9 10-deacetyl-10-(S-methylxanthyl)-7-(triethylsilyl)baccatin III 
• 115437-18-8 7-triethylsilyl-10-deacetylbaccatin III 
• 32981-86-5 10-deacetylbaccatin III 

Downstream Products

• 204981-02-2 C₅₈H₇₇NO₁₃Si₂ 
• 204981-04-4 C₅₄H₆₇NO₁₃SSi 
• 204981-05-5 C₅₄H₆₇NO₁₄Si 
• 204981-03-3 C₅₂H₆₃NO₁₃Si 
• 162664-54-2 2'-O-TBDMS-7-O-TES-9,10-diketo-paclitaxel 

Relevant academic research and scientific papers

Electrochemical Reduction of Taxoids: Selective Preparation of 9-dihydro-, 10-deoxy- and 10-deacetoxy-Taxoids

The electrochemical reduction of docetaxel in methanol in the presence of ammonium chloride leads to 9α-dihydro-docetaxel 3 and 9β-dihydro-docetaxel 4.Under the same conditions, the electrochemical reduction of paclitaxel gives 10-deacetoxy-paclitaxel 7.C

The chemistry of the taxane diterpene: Stereoselective synthesis of 10-deacetoxy-11,12-expoxypaclitaxel

Epoxidation of the olefin in 10-deacetoxybaccatin III (6) and 10-deacetoxypaclitaxel (9) was accomplished with meta-chloroperbenzoic acid leading to a novel pentacyclic ring system. Hydroxyl directed delivery of the epoxidizing agent did not appear to pla

A one-step synthesis of a deuterated paclitaxel analogue: 10-deacetoxy- (10α-2H)paclitaxel

10-Deacetoxy-(10α-2H)paclitaxel was prepared in one step via the samarium diiodide mediated deoxygenation of paclitaxel in the presence of D2O.

METHOD FOR SEPARATION AND PURIFICATION OF 13-DEHYDROXYBACCATIN III AND 10-DEACETYLPACLITAXEL FROM TAXANS-CONTAINING MATERIALS

This invention is directed to a method for efficiently separating and purifying 13-dehydroxybaccatin III and 10-deacetylpaclitaxel with a high purity of 90% or higher purity, preferably 99.5% or higher purity, from taxane-containing materials such as Taxus species, and the thusly obtained highly pure 13-dehydroxybaccatin III and 10-deacetylpaclitaxel can be used as semi-synthetic precursors of paclitaxel and/or docetaxel that are anticancer agents.

Synthesis and interactions of 7-deoxy-, 10-deacetoxy, and 10-deacetoxy-7-deoxypaclitaxel with NCI/ADR-RES cancer cells and bovine brain microvessel endothelial cells

7-Deoxypaclitaxel, 10-deacetoxypaclitaxel and 10-deacetoxy-7- deoxypaclitaxel were prepared and evaluated for their ability to promote assembly of tubulin into microtubules, their cytotoxicity against NCI/ADR-RES cells and for their interactions with P-gl

Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups

Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituen

Synthesis of a novel C-10 spiro-epoxide of paclitaxel

New analogues of paclitaxel (1a, active constituent of Taxol) were synthesized containing an epoxide at the C-10 position. The introduction of the epoxide was carried out by selective removal of the C10-acetate followed by protection of the C2′- and C7-hydroxyl groups. After oxidation to yield a ketone at the C10-position, this intermediate was reacted with dimethylsulfonium ylide. Deprotection and further manipulations provide the C10-spiro epoxide of paclitaxel (1b) and the corresponding C7-MOM ether (1c).

Process for the preparation of 10-desacetoxybaccatin III

A process for abstracting a C10 hydroxy, acyloxy or sulfonyloxy substituent from a taxane in which the C10 hydroxy, acyloxy or sulfonyloxy substituted taxane is reacted with samarium diiodide.

10-desacetoxytaxol derivatives

The present invention relates to 10-desacetoxytaxol and derivatives thereof, which are useful as antitumor agents. These compounds have the formula STR1 wherein R2 is hydrogen, hydroxy or a protected hydroxy group; R3 and R4 are independently hydrogen, hydroxy, a protected hydroxy group, methyl, --SH, --NH2, or --NR8 R9 ; R5 is R10, or --OR10 ; R6 and R7 are independently hydrogen, alkyl, or aryl; R8 and R9 are independently hydrogen, alkyl, alkenyl, alkynyl, or aryl; and R10 is alkoxy, alkyl, alkenyl, alkynl, or aryl.