148136-03-2

Basic information

• Product Name: 4-[2-(4-CHLOROPHENYL)ETHYL]PIPERIDINE HYDROCHLORIDE
• Synonyms: 4-[2-(4-CHLOROPHENYL)ETHYL]PIPERIDINE HYDROCHLORIDE;4-(4-Chlorophenethyl)piperidine hydrochloride
• CAS NO: 148136-03-2
• Molecular Formula: C13H19Cl2N
• Molecular Weight: 260.20266
• Mol File: 148136-03-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[2-(4-CHLOROPHENYL)ETHYL]PIPERIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-(4-CHLOROPHENYL)ETHYL]PIPERIDINE HYDROCHLORIDE(148136-03-2)
• EPA Substance Registry System: 4-[2-(4-CHLOROPHENYL)ETHYL]PIPERIDINE HYDROCHLORIDE(148136-03-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 148136-03-2(Hazardous Substances Data)

Usage

General Description

4-[2-(4-chlorophenyl)ethyl]piperidine hydrochloride is a chemical compound with the molecular formula C15H22ClNO. It is a piperidine derivative with a 4-chlorophenyl group attached to the ethyl side chain. The hydrochloride salt form of this compound is often used as a pharmaceutical agent and is known for its potential as a central nervous system depressant and analgesic. It may also have some potential for use as an anesthetic. The compound's structure and properties make it a subject of interest in medicinal chemistry and drug development.

Relevant articles and documents

Stereoselective Activity of 1-Propargyl-4-styrylpiperidine-like Analogues That Can Discriminate between Monoamine Oxidase Isoforms A and B

The resurgence of interest in monoamine oxidases (MAOs) has been fueled by recent correlations of this enzymatic activity with cardiovascular, neurological, and oncological disorders. This has promoted increased research into selective MAO-A and MAO-B inhibitors. Here, we shed light on how selective inhibition of MAO-A and MAO-B can be achieved by geometric isomers of cis-and trans-1-propargyl-4-styrylpiperidines. While the cis isomers are potent human MAO-A inhibitors, the trans analogues selectively target only the MAO-B isoform. The inhibition was studied by kinetic analysis, UV-vis spectrum measurements, and X-ray crystallography. The selective inhibition of the MAO-A and MAO-B isoforms was confirmed ex vivo in mouse brain homogenates, and additional in vivo studies in mice show the therapeutic potential of 1-propargyl-4-styrylpiperidines for central nervous system disorders. This study represents a unique case of stereoselective activity of cis/trans isomers that can discriminate between structurally related enzyme isoforms.