148146-51-4

Basic information

• Product Name: Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide)
• Synonyms: Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide);Atorvastatin Related CoMpound D;Epoxide iMpurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2-carboxylic acid phenylaMide;Atorvastatin Epoxydione IMpurity;Atorvastatin Epoxide;3-(4-Fluorobenzoyl)-2-(2-Methyl-1-oxopropyl)-N,3-diphenyloxiranecarboxaMide;5-(4-fluorophenyl)-1-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-2-isopropyl-N,4-diphenyl-1H-pyrrole-3-carboxaMide;Atorvastatin IMpurity-C(EP)
• CAS NO: 148146-51-4
• Molecular Formula: C26H22FNO4
• Molecular Weight: 431.4555832
• Product Categories: Amines;Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 148146-51-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 646.611 °C at 760 mmHg
• Flash Point: 344.858 °C
• Appearance: /
• Density: 1.308 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Acetonitrile (Slightly), Chloroform (Slightly, Heated, Sonicated), DMSO (Slightl
• PKA: 13.66±0.70(Predicted)
• BRN: 6162108
• CAS DataBase Reference: Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide)(CAS DataBase Reference)
• NIST Chemistry Reference: Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide)(148146-51-4)
• EPA Substance Registry System: Atorvastatin Related Compound D (20 mg) (Epoxide impurity, or 3-(4-Fluorobenzoyl)-2-isobutyryl-3-phenyl-oxirane-2- carboxylic acid phenylamide)(148146-51-4)

Safety Data

• Hazardous Substances Data: 148146-51-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Atorvastatin (A791750) impurity. An oxidative degradation products of Atorvastatin.

Upstream product

• 134523-03-8 lipitor 
• 134523-00-5 atorvastatin 

Relevant articles and documents

Photodecomposition of CI-981, an HMG-CoA reductase inhibitor

Upon exposure to intense simulated sunlight, CI-981 (1) readily decomposes into three major by-products. This paper reports on the products formed when 1 is decomposed in acetonitrile/water solutions under intense simulated sunlight, ultraviolet light filtered at 254 nm and visible light. Included is a discussion of the isolation of the major by-products and possible mechanisms for the photooxidative processes which lead to them.

Process for the production of atorvastatin calcium un amorphous form

A process for the production of amorphous atorvastatin calcium and stabilized, amorphous atorvastatin calcium is provided.