148148-46-3Relevant academic research and scientific papers
Potassium tert-butoxide-mediated metal-free synthesis of sulfonamides from sodium sulfinates and N,N-disubstituted formamides
Bao, Xiaodong,Rong, Xiaona,Liu, Zhiguo,Gu, Yugui,Liang, Guang,Xia, Qinqin
, p. 2853 - 2858 (2018)
By using formamides as amine sources, a novel and efficient KO-t-Bu mediated amination of sodium sulfinates has been developed. The reaction utilizes readily available starting materials under metal-free conditions, thus providing an alternative and attractive route to sulfonamides.
Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use
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, (2008/06/13)
PCT No. PCT/US98/23482 Sec. 371 Date Feb. 7, 2000 Sec. 102(e) Date Feb. 7, 2000 PCT Filed Nov. 4, 1998 PCT Pub. No. WO99/26616 PCT Pub. Date Jun. 3, 1999The present invention provides compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of diseases whose treatment benefits from the inhibition of phosphodiesterase (PDE-IV) or Tumor Necrosis Factor (TNF) including asthma, allergic diseases, rheumatoid arthritis, osteoarthritis, septic shock. The compounds provided by this invention have formula (I) wherein R1, R2, R3, R4 are as defined herein.
